NEK11 Antibody
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货号:CSB-PA844052LA01HU
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规格:¥440
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促销:
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图片:
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Western blot
All lanes: NEK11 antibody at 7μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 75, 55, 56, 69 kDa
Observed band size: 75 kDa -
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA844052LA01HU at dilution of 1:100
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) NEK11 Polyclonal antibody
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Uniprot No.:Q8NG66
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基因名:NEK11
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别名:4932416N14Rik antibody; FLJ23495 antibody; NEK11 antibody; NEK11_HUMAN antibody; NEK11S/L antibody; Never in mitosis A-related kinase 11 antibody; NIMA (never in mitosis gene a) related kinase 11 antibody; NIMA (never in mitosis gene a)- related kinase 11 antibody; NIMA related kinase 11L antibody; NIMA related kinase 11S antibody; NIMA-related kinase 11 antibody; NimA-related protein kinase 11 antibody; Serine/threonine-protein kinase Nek11 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Serine/threonine-protein kinase Nek11 protein (245-482AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,NEK11 Antibody (CSB-PA844052LA01HU),的标记方式是Non-conjugated。对于NEK11 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
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基因功能参考文献:
- contributes to response of colorectal cancer cells to genotoxic agents and is essential for survival either with or without exposure to DNA damage PMID: 26501353
- Results show that downregulation of NEK11 in drug resistant cells might contribute to drug resistance in ovarian cancer. PMID: 24969318
- NEK11 controls degradation of CDC25A by directly phosphorylating CDC25A on residues whose phosphorylation is required for beta-TrCP mediated CDC25A polyubiquitylation and degradation. PMID: 20090422
- Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway PMID: 12154088
- Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells PMID: 15161910
- NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. PMID: 19734889
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亚细胞定位:Nucleus. Nucleus, nucleolus.
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蛋白家族:Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
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组织特异性:Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
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数据库链接:
HGNC: 18593
OMIM: 609779
KEGG: hsa:79858
STRING: 9606.ENSP00000372857
UniGene: Hs.657336
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