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NEFM Antibody

  • 货号：
    CSB-PA298176
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA298176(NEFM Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA298176(NEFM Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P07197
  • 基因名：
    NEFM
  • 别名：
    150kDa medium antibody; 160 kDa neurofilament protein antibody; 2 kDa neurofilament protein antibody; 200 kDa neurofilament protein antibody; 68 kDa neurofilament protein antibody; AI847934 antibody; CMT1F antibody; CMT2CC antibody; CMT2E antibody; FLJ53642 antibody; KIAA0845 antibody; light molecular weight neurofilament protein antibody; Micro glutamic acid-rich protein antibody; mKIAA0845 antibody; Nef3 antibody; NEFH antibody; NEFL antibody; NEFM antibody; Neurofilament 3 antibody; Neurofilament heavy polypeptide 200kDa antibody; Neurofilament heavy polypeptide antibody; Neurofilament light polypeptide 68kDa antibody; Neurofilament light polypeptide antibody; Neurofilament medium polypeptide 150kDa antibody; Neurofilament medium polypeptide antibody; Neurofilament protein heavy polypeptide antibody; Neurofilament protein light chain antibody; Neurofilament protein light polypeptide antibody; Neurofilament protein medium polypeptide antibody; neurofilament subunit NF-L antibody; Neurofilament triplet H protein antibody; Neurofilament triplet L protein antibody; Neurofilament triplet M protein antibody; neurofilament-3 (150 kD medium) antibody; NF-H antibody; NF-L antibody; NF-M antibody; NF160 antibody; NF165 antibody; NF200 antibody; NF68 antibody; NFH antibody; NFL antibody; NFM antibody; NFM_HUMAN antibody; PPP1R110 antibody; protein phosphatase 1, regulatory subunit 110 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human NEFM
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
  • 基因功能参考文献：
    1. Study determined that spinophilin binding to neurofilament medium required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5. PMID: 28634551
    2. NEFM is a negative regulator of aldosterone production and cell proliferation, in part by facilitating D1R internalization from the plasma membrane in Adosterone-producing Adenomas. PMID: 28584012
    3. There was a strongly elevated reactivity against neurofilament medium in a subset of schizophrenia patients compared to controls. PMID: 24636402
    4. direct evidence that NF-M/H are hyperphosphorylated in Alzheimer disease PMID: 20624930
    5. the importance of alpha-internexin and NF-L in regulating the conformations of NF-M and NF-H PMID: 20213320
    6. This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
    7. To study if the increase of levels of neurofilament (NF)-M and NF-L in brain of Alzheimer's diseases (AD) is caused by increase of NF-M and NF-L. PMID: 12133495
    8. Two polymorphisms of neurofilament M(Ala475Thr and Gly697Arg) occurred at similar frequencies in PD patients and controls. A Pro725Gln substitution and a deletion of valine in position 829 were identified in two PD patients. PMID: 14583397
    9. The G336S variant of hNF-M does not affect the formation of IF networks nor the distribution of the variant hNFM protein. If the G336S variant is involved in the development of PD, it isn't due to defects in the assembly and distribution of NFs. PMID: 15290901
    10. O-glycosylation of NF-M is highly dynamic and closely interwoven with phosphorylation cascades and may have a pathophysiological role. PMID: 16006557
    11. mutations in neurofilaments are possible risk factors that may contribute to pathogenesis in amytrophic lateral sclerosis in conjunction with one or more additional genetic or environmental factors, but are not significant primary causes PMID: 16084104
    12. variation in NEF3 influence rate of response to typical antipsychotic medication PMID: 16734940

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, axon.
  • 蛋白家族：
    Intermediate filament family
  • 数据库链接：

    HGNC: 7734

    OMIM: 162250

    KEGG: hsa:4741

    STRING: 9606.ENSP00000221166

    UniGene: Hs.458657