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NDUFB6 Antibody

  • 货号：
    CSB-PA015653LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate, Mouse heart tissue, Mouse liver tissue, Mouse spleen tissue, Mouse lung tissue, Mouse kidney tissue, Mouse brain tissue, Mouse skeletal muscle tissue, Mouse thymus tissue
      All lanes: NDUFB6 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 16, 14 kDa
      Observed band size: 16, 14 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA015653LA01HU at dilution of 1:100
    • Immunoprecipitating NDUFB6 in HEK293 whole cell lysate
      Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA015653LA01HU in HEK293 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA015653LA01HU (4µg) + HEK293 whole cell lysate (500µg)
      Lane 3: HEK293 whole cell lysate (20µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NDUFB6 Polyclonal antibody
  • Uniprot No.：
    O95139
  • 基因名：
  • 别名：
    NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Complex I-B17; CI-B17; NADH-ubiquinone oxidoreductase B17 subunit
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 protein (2-67AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NDUFB6 Antibody (CSB-PA015653LA01HU)，的标记方式是Non-conjugated。对于NDUFB6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015653LB01HU NDUFB6 Antibody, HRP conjugated ELISA
    FITC CSB-PA015653LC01HU NDUFB6 Antibody, FITC conjugated
    Biotin CSB-PA015653LD01HU NDUFB6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
  • 基因功能参考文献：
    1. we propose that NDUFB6 is a possible tumor suppressor of metastatic ccRCCs. PMID: 25315157
    2. NDUFS6 has a Zn-binding site and is essential for biogenesis of mitochondrial complex I PMID: 25902503
    3. NDUFB6 subunit is required for complex I activity. PMID: 21964293
    4. Results demonstrate that genetic, epigenetic, and nongenetic factors associate with NDUFB6 expression in human muscle and suggest that genetic and epigenetic factors may interact to increase age-dependent susceptibility to insulin resistance. PMID: 17948130
    5. Polymorphism in the NDUFB6 gene from respiratory chain complex I related to ATP synthesis and insulin sensitivity response to exercise training found in relatives of humans with type 2 diabetes. PMID: 19265027

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  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
  • 蛋白家族：
    Complex I NDUFB6 subunit family
  • 数据库链接：

    HGNC: 7701

    OMIM: 603322

    KEGG: hsa:4712

    STRING: 9606.ENSP00000369176

    UniGene: Hs.493668