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NDUFAF1 Antibody

  • 货号：
    CSB-PA897101LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA897101LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA897101LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NDUFAF1 Polyclonal antibody
  • Uniprot No.：
    Q9Y375
  • 基因名：
  • 别名：
    CGI 65 antibody; CGI65 antibody; CIA30 antibody; CIA30_HUMAN antibody; Complex I intermediate associated protein 30 antibody; Complex I intermediate associated protein 30 mitochondrial antibody; Complex I intermediate-associated protein 30; mitochondrial antibody; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 1 antibody; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1 antibody; NADH:ubiquinone oxidoreductase complex assembly factor 1 antibody; NDUFAF 1 antibody; Ndufaf1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Complex I intermediate-associated protein 30, mitochondrial protein (25-327AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NDUFAF1 Antibody (CSB-PA897101LA01HU)，的标记方式是Non-conjugated。对于NDUFAF1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA897101LB01HU NDUFAF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA897101LC01HU NDUFAF1 Antibody, FITC conjugated
    Biotin CSB-PA897101LD01HU NDUFAF1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Chaperone protein involved in early stages of the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
  • 基因功能参考文献：
    1. a case of leukodystrophy associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFAF1 gene. PMID: 24963768
    2. oncogenic K-Ras is able to induce significant alterations in mitochondrial protein expression, and identified NDUFAF1 as an important molecule whose low expression contributes to mitochondrial dysfunction induced by K-Ras. PMID: 25714130
    3. NDUFAF1 is an important protein for the assembly/stability of complex I (NADH:ubiquinone oxidoreductase). PMID: 16218961
    4. Study shows a mitochondrial function for Ecsit in the assembly of mitochondrial complex I, an N-terminal targeting signal directs Ecsit to mitochondria, where it interacts with assembly chaperone NDUFAF1. PMID: 17344420
    5. the involvement of NDUFAF1 in the assembly process could be indirect rather than direct via the binding to assembly intermediates PMID: 17383918
    6. CIA30 is a crucial component in the early assembly of complex I and mutations in its gene can cause mitochondrial disease PMID: 17557076

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  • 亚细胞定位：
    Mitochondrion. Mitochondrion matrix.
  • 蛋白家族：
    CIA30 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 18828

    OMIM: 606934

    KEGG: hsa:51103

    STRING: 9606.ENSP00000260361

    UniGene: Hs.106529