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NCOA5 Antibody

  • 货号：
    CSB-PA015544LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, MCF-7 whole cell lysate, Mouse heart tissue, Mouse liver tissue
      All lanes: NCOA5 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 66 kDa
      Observed band size: 66, 35, 25 kDa
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA015544LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NCOA5 Polyclonal antibody
  • Uniprot No.：
    Q9HCD5
  • 基因名：
    NCOA5
  • 别名：
    NCOA5 antibody; KIAA1637 antibody; Nuclear receptor coactivator 5 antibody; NCoA-5 antibody; Coactivator independent of AF-2 antibody; CIA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Nuclear receptor coactivator 5 protein (112-283AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NCOA5 Antibody (CSB-PA015544LA01HU)，的标记方式是Non-conjugated。对于NCOA5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015544LB01HU NCOA5 Antibody, HRP conjugated ELISA
    FITC CSB-PA015544LC01HU NCOA5 Antibody, FITC conjugated
    Biotin CSB-PA015544LD01HU NCOA5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
  • 基因功能参考文献：
    1. knockout of NCOA5 can suppress the epithelial - mesenchymal transition (EMT) in hepatocellular carcinoma cells. PMID: 29626478
    2. This study provides new insights and evidences that NOCA5 over-expression was significantly correlated with progression and prognosis in luminal breast cancer. However, the precise cellular mechanisms for NOCA5 in luminal breast cancer need to be further explored. PMID: 27847318
    3. NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma. PMID: 25416054
    4. suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 deficiency increases susceptibility to both glucose intolerance and HCC, partially by increasing IL-6 expression PMID: 24332041
    5. gene polymorphism confers susceptibility to psoriasis in a Southern European population PMID: 21645569

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 15909

    KEGG: hsa:57727

    STRING: 9606.ENSP00000290231

    UniGene: Hs.654991