NCDN Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) NCDN Polyclonal antibody
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Uniprot No.:Q9UBB6
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基因名:NCDN
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别名:NCDN antibody; KIAA0607 antibody; Neurochondrin antibody
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宿主:Rabbit
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反应种属:Human, Rat
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免疫原:Recombinant Human Neurochondrin protein (403-516AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,NCDN Antibody (CSB-PA015524LA01HU),的标记方式是Non-conjugated。对于NCDN Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC, IF
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:500-1:1000 IF 1:50-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.
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基因功能参考文献:
- Schizophrenia subjects compared to controls showed a marked increase in CA1 hippocampal Norbin, and Tamalin proteins (47% and 34% respectively), which are endogenous regulators of mGluR5 signalling and trafficking PMID: 26048293
- we demonstrate that neurochondrin has strong isoform selectivity towards the RIIa subunit of PKA with nanomolar affinity PMID: 25916936
- In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. PMID: 23687301
- In mouse, the encoded protein is a negative regulator of Ca/calmodulin-dependent protein kinase II phosphorylation and is essential for the spatial learning process. PMID: 15790563
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亚细胞定位:Cytoplasm, cytosol. Endosome membrane; Lipid-anchor. Cell projection, dendrite. Cell junction, synapse, postsynapse.
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蛋白家族:Neurochondrin family
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组织特异性:Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine.
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数据库链接:
HGNC: 17597
OMIM: 608458
KEGG: hsa:23154
STRING: 9606.ENSP00000348394
UniGene: Hs.121870