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NCAPH Antibody

  • 货号：
    CSB-PA621857DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA621857DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NCAPH Polyclonal antibody
  • Uniprot No.：
    Q15003
  • 基因名：
    NCAPH
  • 别名：
    Barren Drosophila Homolog of 1 antibody; Barren homolog protein 1 antibody; BRRN antibody; BRRN1 antibody; CAP H antibody; CAPH antibody; Chromosome associated protein H antibody; Chromosome-associated protein H antibody; CND2_HUMAN antibody; Condensin complex subunit 2 antibody; Condensin subunit 2 antibody; Condensin-2 complex subunit H2 antibody; Condesin antibody; HCAP H antibody; hCAP-H antibody; KIAA0074 antibody; mCAP H antibody; MGC4616 antibody; Ncaph antibody; Non SMC condensin I complex subunit H antibody; Non-SMC condensin I complex subunit H antibody; XCAP H homolog antibody; XCAP-H homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Condensin complex subunit 2 protein (1-250AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
  • 基因功能参考文献：
    1. NCAPH high expression promotes colonic cancerous cell proliferation. PMID: 28300828
    2. Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death. PMID: 21151026
    3. Our results identify a SSB-specific response of condensin I through PARP-1 and demonstrate a role for condensin in SSB. repair. PMID: 16543152
  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • 蛋白家族：
    CND2 (condensin subunit 2) family
  • 组织特异性：
    Widely expressed at low level. Expressed in proliferating cells.
  • 数据库链接：

    HGNC: 1112

    OMIM: 602332

    KEGG: hsa:23397

    STRING: 9606.ENSP00000240423

    UniGene: Hs.308045