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NCAN Antibody

  • 货号：
    CSB-PA722190
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA722190(NCAN Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: CSB-PA722190(NCAN Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    O14594
  • 基因名：
    NCAN
  • 别名：
    Chondroitin sulfate proteoglycan 3 antibody; Cspg3 antibody; Ncan antibody; NCAN_HUMAN antibody; NEUR antibody; Neurocan core protein antibody; Neurocan proteoglycan antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human NCAN
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
  • 基因功能参考文献：
    1. NCAN rs2228603 is not a risk factor for the incidence of NAFLD in Chinese population. The dual and opposite role of T variant in protecting liver with a higher level of HDL was found. PMID: 27887608
    2. This study aims to analyze the influences of single-nucleotide polymorphism in the NCAN-CILP2 region on non-alcoholic fatty liver disease and plasma lipid levels in the Asian and Pacific ethnic groups. PMID: 26758378
    3. NCAN genotype is associated with limbic gray matter alterations in healthy and subjects with major depression in brain areas implicated in emotion perception and regulation PMID: 25801500
    4. current data demonstrate that common genetic variation in NCAN influences both neural processing and cognitive performance in healthy subjects. PMID: 25220293
    5. The frequency of the NCAN rs2228603 T allele was significantly increased in patients with HCC due to ALD (15.1%) compared to alcoholic cirrhosis without HCC (9.3%), alcoholic controls (7.2%), healthy controls (7.9%), and HCV associated HCC (9.1%). PMID: 24946282
    6. NCAN risk variant is associated with cortical folding and thickness in bipolar disorder and schizophrenia. PMID: 23795679
    7. Conditional analysis shows that a neighbouring gene, TM6SF2, not NCAN, is responsible for the Chr 19 GWAS locus previously associated with fibrosing non-alcoholic fatty liver disease (NAFLD). PMID: 24978903
    8. NCAN rs2228603[T] is a risk factor for liver inflammation and fibrosis, suggesting that this locus is responsible for progression from steatosis to steatohepatitis. PMID: 23594525
    9. no genetic association between risk allele A for NCAN locus rs1064395 and schizophrenia. PMID: 23198940
    10. In the combined patient sample, the NCAN risk allele was significantly associated with the "mania" factor, in particular the subdimension "overactivity. PMID: 22952076
    11. The rs1064395 A-allele was significantly over-represented in schizophrenia patients compared to controls. Our data suggest that genetic variation in NCAN is a common risk factor for bipolar disorder and schizophrenia. PMID: 22497794
    12. High neurocan is associated with the invasive phenotype of low-grade astrocytoma. PMID: 21997179
    13. Sex (male)-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels is observed both the Mulao and Han ethnic groups. PMID: 22208664
    14. Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with bipolar disorder. PMID: 21353194

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Aggrecan/versican proteoglycan family
  • 组织特异性：
    Brain.
  • 数据库链接：

    HGNC: 2465

    OMIM: 600826

    KEGG: hsa:1463

    STRING: 9606.ENSP00000252575

    UniGene: Hs.169047