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NCAM2 Antibody

  • 货号：
    CSB-PA020032
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O15394
  • 基因名：
    NCAM2
  • 别名：
    Cell adhesion molecule, neural, 2 antibody; MGC51008 antibody; N CAM 2 antibody; N CAM 21 antibody; N CAM2 antibody; N CAM21 antibody; N-CAM-2 antibody; NCAM 2 antibody; NCAM 21 antibody; NCAM-2 antibody; Ncam2 antibody; NCAM2_HUMAN antibody; NCAM21 antibody; Neural cell adhesion molecule 2 antibody; OCAM GPI antibody; R4B12 antibody; RB 8 neural cell adhesion molecule antibody; RB8 neural cell adhesion molecule antibody; RNCAM antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NCAM2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
  • 基因功能参考文献：
    1. Our reported case raises the questions whether the NCAM2-deletion is the true cause of the autism spectrum disorder or only a risk factor and whether there might be any connection in NCAM2 with skull-size PMID: 27596683
    2. Abeta-dependent disruption of NCAM2 functions in Alzheimer's disease hippocampus contributes to synapse loss. PMID: 26611261
    3. A complete structural model of the entire ectodomain of human NCAM2 has been assembled from crystal structures of six recombinant proteins corresponding to different regions of the ectodomain. PMID: 21300289
    4. High NCAM2 is associated with increased 5-Fluorouracil sensitivity in prostate and breast cancer. PMID: 21214674
    5. In the crystal structure, two Ig domains interact by domain swapping, as the two N-terminal beta-strands are interchanged. PMID: 18706912

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed most strongly in adult and fetal brain.
  • 数据库链接：

    HGNC: 7657

    OMIM: 602040

    KEGG: hsa:4685

    STRING: 9606.ENSP00000383392

    UniGene: Hs.473450