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NBEAL2 Antibody

  • 货号：
    CSB-PA751159LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA751159LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA751159LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NBEAL2 Polyclonal antibody
  • Uniprot No.：
    Q6ZNJ1
  • 基因名：
    NBEAL2
  • 别名：
    BDPLT4 antibody; GPS antibody; NBEAL2 antibody; NBEL2_HUMAN antibody; Neurobeachin-like protein 2 antibody; UNQ253/PRO290 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Neurobeachin-like protein 2 protein (1360-1574AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NBEAL2 Antibody (CSB-PA751159LA01HU)，的标记方式是Non-conjugated。对于NBEAL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA751159LB01HU NBEAL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA751159LC01HU NBEAL2 Antibody, FITC conjugated
    Biotin CSB-PA751159LD01HU NBEAL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.
  • 基因功能参考文献：
    1. observed absence of NBEAL2 in platelets from GPS patients with 3 different genotypes, and reduced/truncated platelet NBEAL2 has been reported for others. PMID: 29869935
    2. NBEAL2 has an essential role in neutrophil and NK cell function and pathogen defense PMID: 28783043
    3. we herein show a long-distance regulatory region with GATA1 binding sites as being a strong enhancer for NBEAL2 expression. PMID: 28082341
    4. NBEAL2 mutation is associated with gray platelet syndrome. PMID: 21765411
    5. Mutations in NBEAL2, encoding a BEACH protein is associated with gray platelet syndrome. PMID: 21765413

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  • 相关疾病：
    Gray platelet syndrome (GPS)
  • 亚细胞定位：
    Endoplasmic reticulum.
  • 蛋白家族：
    WD repeat neurobeachin family
  • 组织特异性：
    Expressed in megakaryocytes.
  • 数据库链接：

    HGNC: 31928

    OMIM: 139090

    KEGG: hsa:23218

    STRING: 9606.ENSP00000415034

    UniGene: Hs.437043