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NANOS3 Antibody

  • 货号：
    CSB-PA015438LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA015438LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA015438LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NANOS3 Polyclonal antibody
  • Uniprot No.：
    P60323
  • 基因名：
    NANOS3
  • 别名：
    NANO3_HUMAN antibody; Nanos homolog 3 antibody; NANOS3 antibody; NOS-3 antibody; Nos3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nanos homolog 3 protein (21-192AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NANOS3 Antibody (CSB-PA015438LA01HU)，的标记方式是Non-conjugated。对于NANOS3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015438LB01HU NANOS3 Antibody, HRP conjugated ELISA
    FITC CSB-PA015438LC01HU NANOS3 Antibody, FITC conjugated
    Biotin CSB-PA015438LD01HU NANOS3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
  • 基因功能参考文献：
    1. despite the prominent role of NANOS3 in ovarian development, our findings suggest that NANOS3 mutations were not associated with POF in the present cohort of Brazilian women. PMID: 28076512
    2. data can be used to further elucidate the role of NANOS3 and DAZL in germ cell development both in vitro and in vivo PMID: 27768780
    3. NANOS3 has role in the acquisition of invasiveness by human lung tumour cells and propose a new mechanism of post-transcriptional regulation of epithelial-mesenchymal transition. PMID: 25904364
    4. an inactivating missense mutation in NANOS3 has a role in primary ovarian insufficiency that involves increased primordial germ cell apoptosis during embryonic cell migration PMID: 25054146
    5. NANOS3 mutation is one possible cause of primary ovarian insufficiency. PMID: 24091668
    6. NANOS3 modulates essential aspects of human germ cell development perhaps during the cell cycle. PMID: 21421998
    7. Mutations in NANOS3 exons are rare in both Chinese and Caucasian women with premature ovarian failure. PMID: 17418157
    8. Report for the first time analysis of the NANOS3 gene in infertile males. PMID: 19565640
    9. Observational study of genotype prevalence. (HuGE Navigator) PMID: 17418157

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body.
  • 蛋白家族：
    Nanos family
  • 组织特异性：
    Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, ty
  • 数据库链接：

    HGNC: 22048

    OMIM: 608229

    KEGG: hsa:342977

    UniGene: Hs.127982