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NANOS1 Antibody

  • 货号：
    CSB-PA837878LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of Hela cells using CSB-PA837878LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NANOS1 Polyclonal antibody
  • Uniprot No.：
    Q8WY41
  • 基因名：
    NANOS1
  • 别名：
    EC Rep1a antibody; EC_Rep1a antibody; NANO1_HUMAN antibody; NANOS 1 antibody; Nanos homolog 1 (Drosophila) antibody; Nanos homolog 1 antibody; Nanos Homologue 1 (NANOS1) antibody; NANOS1 antibody; Nos 1 antibody; NOS-1 antibody; Nos1 antibody; OTTHUMP00000046853 antibody; Rep 1a antibody; Rep1a antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nanos homolog 1 protein (1-292AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NANOS1 Antibody (CSB-PA837878LA01HU)，的标记方式是Non-conjugated。对于NANOS1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA837878LB01HU NANOS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA837878LC01HU NANOS1 Antibody, FITC conjugated
    Biotin CSB-PA837878LD01HU NANOS1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
  • 基因功能参考文献：
    1. High NANOS expression is associated with retinoblastoma. PMID: 25100735
    2. A group of 195 patients manifesting non-obstructive azoospermia or oligozoospermia were tested for mutations of the NANOS1 gene. PMID: 23315541
    3. Single nucleotide polymorphisms in CYP26B1, NANOS1 and STRA8 genes support involvement of meiotic program initiation in modifying azoospermia and oligozoospermia risk in a Han-Chinese population PMID: 23320086
    4. NANOS1-PUMILIO2 complex, together with GEMIN3 and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells. PMID: 21800163
    5. Findings describe a new function for hNanos1 as a downstream effector of E-cadherin loss contributing to tumor progression. PMID: 17047063
    6. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. PMID: 18223680
    7. Data demonstrated that SNAPIN interacts additionally with NANOS1 protein. This is the first report demonstrating that the N-terminal region of NANOS1 is necessary for protein binding. PMID: 19168546

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  • 相关疾病：
    Spermatogenic failure 12 (SPGF12)
  • 亚细胞定位：
    Cytoplasm, perinuclear region. Cytoplasm.
  • 蛋白家族：
    Nanos family
  • 组织特异性：
    Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermat
  • 数据库链接：

    HGNC: 23044

    OMIM: 608226

    KEGG: hsa:340719

    STRING: 9606.ENSP00000393275

    UniGene: Hs.591918