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NACC1 Antibody

  • 货号：
    CSB-PA283286
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from Rat and Mouse brain tissue using NAC1 Antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NACC1 Polyclonal antibody
  • Uniprot No.：
    Q96RE7
  • 基因名：
    NACC1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence around aa.519~523(A-G-P-S-A) derived from Human NAC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
  • 基因功能参考文献：
    1. knockdown of HOXA9 abrogated NAC1induced drug resistance. PMID: 28713930
    2. NAC1 forms a protein complex to function as a transcriptional regulator in cancer cells PMID: 27424155
    3. a mutation in NACC1 causes microcephaly, profound developmental delays and/or intellectual disability, cataracts, severe epilepsy including infantile spasms, irritability, failure to thrive, and stereotypic hand movements PMID: 28132692
    4. miR-339-5p inhibits migration and invasion in ovarian cancer by targeting NACC1 and BCL6. miR-339-5p may be a biomarker of metastasis in ovarian cancer; NACC1 had a predictive value for ovarian cancer progression PMID: 26553360
    5. NAC1 has potential as a marker for distinguishing OED from CIS/OSCC PMID: 26172271
    6. NACC1 can be modified by SUMO paralogues, and cooperates with promyelocytic leukemia protein. PMID: 25891951
    7. strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1/BCL6 and of Miz1/NAC1 are reported PMID: 25484205
    8. low expression of NAC1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma. PMID: 23252869
    9. The identification of an NAC1 NLS thus clarifies the mechanism through which NAC1 translocates to the nucleus to regulate the transcription of genes involved in oncogenicity and pluripotency. PMID: 22665369
    10. Uterine sarcomas with NAC1 overexpression are clinically the most aggressive, chemoresistant, and radioresistant tumors. PMID: 22993327
    11. Results not only reveal a previously unrecognized function of NAC1, the molecular pathway involved and its impact on pathogenesis of tumor initiation and development, but also identify a novel senescence regulator PMID: 22665267
    12. NAC1 expression was significantly correlated with FASN expression in both OCCC samples and OCCC cell lines. PMID: 22653145
    13. NAC1 overexpression is critical to the growth and survival of cervical carcinomas irrespective of histologic type. PMID: 21889186
    14. NAC1 is identified as a novel regulator of autophagy PMID: 21743489
    15. These data suggest that the acetylation status of CTTN modulated by the NACC1-HDAC6 deacetylation system induces acceleration of melanoma cell migration activity via an actin-dependent cellular process PMID: 21562571
    16. Our data suggest that amplification at the ch19p13.2 NACC1 locus, leading to NAC1 overexpression, is one of the molecular genetic alterations associated with early tumor recurrence in ovarian cancer. PMID: 21240255
    17. These results indicate that a cell cycle-dependent regulatory mechanism controls NAC1 body formation in the nucleus and suggest that NAC1 body dynamics are associated with mitosis or cytokinesis. PMID: 21301057
    18. NAC1 is a potential stem cell pluripotency factor expression in normal endometrium, endometrial hyperplasia and endometrial carcinoma PMID: 20372782
    19. NAC1 over-expression is critical to the growth and survival of ovarian cancers. Furthermore, they suggest that NAC1 silencing RNA-induced phenotypes depend on the expression status of the targeted cell line. PMID: 20869761
    20. NAC-1 is a tumor recurrence-associated gene with oncogenic potential; interactions between BTB/POZ domains of NAC-1 proteins are critical to form the discrete NAC-1 nuclear bodies and essential for tumor cell proliferation and survival. PMID: 17130457
    21. NAC-1 expression is higher in ovarian carcinoma cells in effusions compared with their solid tumor counterparts. PMID: 17391728
    22. NAC-1 may play an important role in cervical carcinomas. PMID: 18347169
    23. NAC-1 regulates Taxol resistance in ovarian cancer PMID: 18483383
    24. Therefore, we conclude that NAC1 functions as a corepressor for POZ/BTB proteins expressed in the mature CNS. PMID: 19121354
    25. NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer by inactivating Gadd45v pathway. PMID: 19305429
    26. C-terminal alpha-helix of the Nac1 POZ domain is shorter than that observed in most other POZ-domain transcription factors PMID: 19407373

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  • 相关疾病：
    Neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination (NECFM)
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence.
  • 数据库链接：

    HGNC: 20967

    OMIM: 610672

    KEGG: hsa:112939

    STRING: 9606.ENSP00000292431

    UniGene: Hs.531614