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NABP2 Antibody

  • 货号：
    CSB-PA016250GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BQ15
  • 基因名：
    NABP2
  • 别名：
    NABP2 antibody; OBFC2B antibody; SSB1 antibody; LP3587 antibody; SOSS complex subunit B1 antibody; Nucleic acid-binding protein 2 antibody; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B antibody; Sensor of single-strand DNA complex subunit B1 antibody; Sensor of ssDNA subunit B1 antibody; SOSS-B1 antibody; Single-stranded DNA-binding protein 1 antibody; hSSB1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human OBFC2B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
  • 基因功能参考文献：
    1. findings demonstrate a novel hSSB1 regulatory mechanism for the repair of damaged DNA PMID: 27273218
    2. Our data highlights that BLM helicase and hSSB1 function in a dynamic complex in cells and that this complex is likely required for BLM protein stability and function. PMID: 28506294
    3. the detailed molecular mechanism in solution of ssDNA binding by hSSB1, a major player in the maintenance of genomic stability, is reported. PMID: 27387285
    4. In the absence of hSSB1, human 8-oxoguanine glycosylase 1 does not localize to chromatin, resulting in the accumulation of 8-oxoguanine in the genome. PMID: 26261212
    5. The findings demonstrate the importance of hSSB1 in maintaining and repairing DNA replication forks and for overall genomic stability. PMID: 24753408
    6. Identification of EEf1E1 and OBFC2B as novel BRCA1-partner genes in the DNA double-strand break repair pathway. PMID: 24104880
    7. SOSS complexes, containing SSB1, do not localize with Replication Protein A (RPA) to replication sites in human cells, yet have a strong effect on double-strand break resection and homologous recombination. PMID: 23178594
    8. Cells deficient in hSSB1 exhibit increased radiosensitivity, defective checkpoint activation and enhanced genomic instability coupled with a diminished capacity for DNA repair. PMID: 18449195
    9. INTS3 controls the SSB1-mediated DNA damage response. PMID: 19786574

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  • 亚细胞定位：
    Nucleus. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
  • 蛋白家族：
    SOSS-B family, SOSS-B1 subfamily
  • 数据库链接：

    HGNC: 28412

    OMIM: 612104

    KEGG: hsa:79035

    STRING: 9606.ENSP00000267023

    UniGene: Hs.240170