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NAB2 Antibody

  • 货号：
    CSB-PA003366
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of RAW264.7 cells using NAB2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q15742
  • 基因名：
    NAB2
  • 别名：
    EGR 1 binding protein 2 antibody; EGR-1-binding protein 2 antibody; EGR1 binding protein 2 antibody; MADER antibody; Melanoma associated delayed early response protein antibody; Melanoma-associated delayed early response protein antibody; MGC75085 antibody; Nab 2 antibody; nab2 antibody; NAB2_HUMAN antibody; NGFI A binding protein 2 (EGR1 binding protein 2) antibody; NGFI A binding protein 2 antibody; NGFI-A-binding protein 2 antibody; Protein MADER antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NAB2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.
  • 基因功能参考文献：
    1. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours. PMID: 28072477
    2. Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor PMID: 26927892
    3. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion and helps to discriminate SFTs from histological mimics. PMID: 24702701
    4. Variants of the NAB2-STAT6 fusion gene are found in solitary fibrous tumors of the meninges. PMID: 27271270
    5. NAB2-STAT6 fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain. PMID: 26746203
    6. the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type. PMID: 26686340
    7. Case Report: NAB2-STAT6 fusion in glioblastoma. PMID: 26817999
    8. We delineate the common and rare NAB2-STAT6 fusion variants in solitary fibrous tumors PMID: 26226844
    9. This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 nuclear expression and NAB2-STAT6 fusion similar to their soft tissue counterparts. PMID: 26883114
    10. It is associated with local recurrence and late distance metastasis of brain tumors to extracranial sites. PMID: 25893823
    11. This study validated the existence of the NAB2-STAT6 fusion gene in solitary fibrous tumors and examined its relation with pathological features. PMID: 25554652
    12. also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17 PMID: 26136329
    13. There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201). PMID: 25582503
    14. reverse transcriptase PCR analysis identified a nerve growth factor inducible-A binding protein 2-STAT6 gene fusion. Our case supports the utility of STAT6 immunohistochemistry as an adjunct in the diagnosis of soft-tissue SFT with loss of CD34 positivity PMID: 25667482
    15. Tumors with the most common fusion variant, NAB2ex4-STAT6ex2/3, corresponded to classic pleuropulmonary solitary fibrous tumors with diffuse fibrosis and mostly benign behavior and occurred in older patients PMID: 24513261
    16. 44 SFTs were studied to identify pathogenetically important genetic rearrangements. RT-PCR analysis identified a NAB2/STAT6 fusion in 37/41 cases. PMID: 23761323
    17. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion PMID: 23575898
    18. NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells. PMID: 23416169
    19. A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 is the defining driver mutation of solitary fibrous tumor. PMID: 23313952
    20. A NAB2-STAT6 fusion is a distinct molecular feature of solitary fibrous tumors. PMID: 23313954
    21. p130Cas signaling induces the expression of EGR1 and NAB2 PMID: 22431919
    22. Results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop. PMID: 20506119
    23. Nab2 is a novel endogenous negative regulator of Egr-1-dependent TGF-beta signaling responsible for setting the intensity of fibrotic responses PMID: 19888474
    24. mutations in the human NAB2 gene are most likely not involved in the pathogenesis of peripheral neuropathies. PMID: 12030330
    25. inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. PMID: 12427750
    26. Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter in a negative feedback loop PMID: 16260776

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NAB family
  • 组织特异性：
    Widely expressed at low levels. Highly expressed in melanoma cell lines.
  • 数据库链接：

    HGNC: 7627

    OMIM: 602381

    KEGG: hsa:4665

    STRING: 9606.ENSP00000300131

    UniGene: Hs.159223