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  4. NAA10 Antibody

NAA10 Antibody

  • 货号：
    CSB-PA001984GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P41227
  • 基因名：
    NAA10
  • 别名：
    Alpha N acetyltransferase 1A antibody; ARD1 antibody; ARD1 homolog N acetyltransferase (S. cerevisiae) antibody; ARD1 homolog A N acetyltransferase (S. cerevisiae) antibody; ARD1 homolog A N acetyltransferase antibody; ARD1A antibody; DXS707 antibody; MGC71248 antibody; N acetyltransferase ARD1, human homolog of antibody; N alpha acetyltransferase 10 NatA catalytic subunit antibody; N terminal acetyltransferase complex ARD1 subunit homolog A antibody; N(alpha) acetyltransferase 10 NatA catalytic subunit antibody; N-alpha-acetyltransferase 10 antibody; N-terminal acetyltransferase complex ARD1 subunit homolog A antibody; Naa10 antibody; NAA10_HUMAN antibody; NatA catalytic subunit antibody; TE2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ARD1A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis.
  • 基因功能参考文献：
    1. Since the FIH-1 dependent hydroxylation of NAA10 occurs oxygen-dependently, NAA10 acetylates HIF-1alpha under normoxia but does not under hypoxia. PMID: 30237125
    2. In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity PMID: 28585574
    3. ARD1-mediated Hsp70 acetylation is a regulatory mechanism that temporally balances protein refolding/degradation in response to stress PMID: 27708256
    4. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation. PMID: 27910960
    5. A novel de novo NAA10 c.332 T>G p.(Val111Gly) missense variant was detected in a girl with mild/moderate non-syndromic intellectual disability. NAA10 V111G displayed reduced monomeric NAT activity and stability, but intact NatA-mediated NAT activity. PMID: 29558889
    6. Expression of ARD1 increases levels of androgen receptor acetylation and androgen receptor-HSP90 dissociation in a dose dependent manner. PMID: 27659526
    7. Study reports on a total of 12 affected females with four different de novo missense mutations in NAA10 and one inherited mutation in a familial case due to germline mosaicism, thus further expanding themutational and clinical spectrum associated with NAA10 related N-terminal-acetyltransferase deficiency. PMID: 27094817
    8. our study illustrated that the expression of Naa10p had a potential value for predicting the progression of OSCC and prognosis of OSCC patients. PMID: 26662107
    9. The results observed an inverse correlation between the expression of NAA10 and that of miR-342-5p and miR-608 . PMID: 26646451
    10. Human Naa15 (NATH) and Naa10 (ARD1) form a stable NatA complex which associates with ribosomes and performs co-translational N-terminal acetylation; Naa15 (NATH) and Naa10 (ARD1) are cleaved during apoptosis resulting in decreased acetyltransferase activity PMID: 15496142
    11. The clinical spectrum of NAA10. PMID: 26522270
    12. there is no difference in lysine acetylation of substrate proteins with or without Naa10, suggesting that the substrates may be acetylated chemically rather than enzymatically. PMID: 26755727
    13. Combined high expression of Naa10p, SNCG and PRL-3 are associated with lymph node metastasis in breast cancer. PMID: 25854368
    14. De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females PMID: 25099252
    15. human ARD1 variants have different effects on cell proliferation, which may result from distinct subcellular localizations and autoacetylation activities. PMID: 25421966
    16. Naa10 structure and function. [Review] PMID: 25987439
    17. Autoacetylation of ARD1 variants differentially regulates angiogenesis and cell proliferation in an isoform-specific manner. PMID: 25338643
    18. ARD1 has a crucial role in the cellular response to oxidative stress as a bona fide regulator of MSRA. PMID: 25341044
    19. Naa10p inhibits the metastasis of breast cancer cells by targeting STAT5a. PMID: 24925029
    20. results show that hARD1 nuclear translocation mediated by NLS is required for cell cycle progression, thereby contributing to proper cell proliferation. PMID: 25133627
    21. Study describes a Saccharomyces cerevisiae model developed by introducing the human wild-type (wt) or mutant NatA complex into yeast lacking NatA (NatA-Delta). The wt human NatA complex phenotypically complemented the NatA-Delta strain, whereas only a partial rescue was observed for the Ogden mutant NatA complex suggesting that hNaa10 S37P is only partially functional in vivo. PMID: 24408909
    22. The study concludes that the NAA10 mutation is the cause of Lenz microphthalmia syndrome in a family, likely through the dysregulation of the retinoic acid signalling pathway. PMID: 24431331
    23. Protein N-terminal acetyltransferases (NATs), including Naa10, act as N-terminal propionyltransferases. PMID: 23043182
    24. Development of the first specific NAT-inhibitors, including inhibitors targeting Naa10. PMID: 23557624
    25. Structural characterization of native hARD1 using size exclusion chromatography, circular dichroism, & fluorescence spectroscopy shows the protein consists of compact globular region comprising 2 thirds of the protein & a flexible unstructured C terminus. PMID: 16823041
    26. ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development PMID: 20145209
    27. These results indicate that ARD1A is a novel tumor-associated antigen and a potential prognostic factor for colon cancer. PMID: 20639454
    28. The expression level of NAA10 is inversely correlated with that of MMP-9 in breast cancer samples. PMID: 23550278
    29. Naa10p suppresses 28S proteasome activity through interaction with PA28beta. PMID: 23624078
    30. These data indicate that the interaction between ARD1 and RIP1 plays an important role in the DNA damage-induced NF-kappaB activation, and that the acetyltransferase activity of ARD1 and its localization in to the nucleus are involved in such stress response. PMID: 22580278
    31. study revealed a novel mechanism controlling MCL1 expression, in which Naa10p and RelA/p65 synergistically interact with MCL1 promoter region and promote MCL1 transcription PMID: 22496479
    32. Arrest-defective protein 1 homolog A (ARD1) in combination with SNCG/Hiwi/PRL-3 may lead to a poor outcome in patients with or without lymph node metastatic colon cancer. PMID: 22261620
    33. ARD1 functions as a unique AR regulator in prostate cancer cells. PMID: 22315407
    34. A reduction in acetylation by hNaa10p causes lethal X-linked disorder of infancy. PMID: 21700266
    35. N(alpha)-acetyltransferase 10 may function as a post-translational actin N(alpha)-acetyltransferase. PMID: 21383206
    36. suggest that Naa10p functions as a tumor metastasis suppressor by disrupting the migratory complex, PIX-GIT- Paxillin, in cancer cells PMID: 21295525
    37. interaction between hNaa10p and DNMT1 was required for E-cadherin silencing through promoter CpG methylation, and E-cadherin repression contributed to the oncogenic effects of hNaa10p. PMID: 20592467
    38. Results show that hARD1 autoacetylation is critical for its activation and its ability to stimulate cancer cell proliferation and tumorigenesis. PMID: 20501853
    39. Data indicate that the physical interaction between HYPK and NatA Naa10/15 seems to be of functional importance both for huntingtin aggregation and for N-terminal acetylation. PMID: 20154145
    40. hARD1 is a bona fide regulator of MLCK, and hARD1 plays a crucial role in the balance between tumor cell migration and stasis PMID: 19826488
    41. ARD1-mediated acetylation regulates and destabilizes HIF-1 alpha by directly binding to it. PMID: 12464182
    42. description of the human homologue of Nat1p, NATH (NAT human), as the binding partner of the hARD1 (human ARD1) protein PMID: 15496142
    43. Amino-terminal acetyltransferase ARD1 (hARD1) interacts with a novel motif, 658-HGVVEVD-664, in the cytoplasmic domain of beta-amyloid precursor protein. PMID: 15749829
    44. ARD1 is involved in cell proliferation and in regulating a series of cellular metabolic pathways that are regulated during hypoxia response. PMID: 15755738
    45. Data demonstrate that ARD1 has limited, if any, impact on the HIF-1alpha signaling pathway. PMID: 15994306
    46. levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures PMID: 16279846
    47. ARD1 specifically binds HIF-1 alpha, suggesting a putative, still unclear, connection between these proteins. PMID: 16288748
    48. A human ARD1 variant ortholog (235) has weak effects on hypoxia inducible factor (HIF)-1 alpha and VEGF mRNA stability compared to mouse ARD1 ortholog 225. PMID: 16376303
    49. Essential role in cell survival through protein N-alpha-acetylation. PMID: 16518407
    50. These results indicate that ARD1(235) and ARD1(225) isoforms may have different activities and function in different subcellular compartments of mammalian cells. PMID: 17161380

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  • 相关疾病：
    N-terminal acetyltransferase deficiency (NATD); Microphthalmia, syndromic, 1 (MCOPS1)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Acetyltransferase family, ARD1 subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 18704

    OMIM: 300013

    KEGG: hsa:8260

    STRING: 9606.ENSP00000417763

    UniGene: Hs.433291