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Maged1 Antibody

  • 货号：
    CSB-PA234148
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from PC12 cells using Melanoma-associated antigen D1 Antibody and the same antibody preincubated with blocking peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Maged1 Polyclonal antibody
  • Uniprot No.：
    Q9QYH6
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse,Rat
  • 免疫原：
    Peptide with sequence C-EAEARAEARNRMGIGDE derived from Mouse Melanoma-associated antigen D1.
  • 免疫原种属：
    Mus musculus (Mouse)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
  • 基因功能参考文献：
    1. Both transient and stable expression of Necdin induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation. PMID: 28528976
    2. MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model PMID: 26272363
    3. Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB). PMID: 24700102
    4. NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB signalling pathway. PMID: 25736627
    5. Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src-dependent manner that is negatively regulated by NRAGE. PMID: 23142633
    6. We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes PMID: 22865874
    7. Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD) PMID: 23300464
    8. the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT ubiquitylation. PMID: 22457503
    9. XIAP-TAB1-TAK1 complex is dependent on NRAGE for IKK-alpha/beta phosphorylation and NF-kappaB activation. PMID: 21789165
    10. MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1, Rev-erbalpha and E4bp4 expression through the Rev-Erbalpha/ROR responsive elements (RORE). PMID: 20300063
    11. NRAGE induces NF-kappaB activation and MIF expression in P19 cells PMID: 20100315
    12. MHD2 of NRAGE was not necessary for BMP-induced p38MAPK activation or caspase-mediated apoptosis. PMID: 19937275
    13. roles for NRAGE as a mediator of precursor apoptosis and a repressor of cell cycle progression in neural development PMID: 12204258
    14. receptor tyrosine kinase-like orphan receptor 2(Ror2) sequesters Dlxin-1 in membranous compartments, thereby affecting the transcriptional function of Mhomeobox, msh-like 2(msx2) PMID: 12754255
    15. The expression pattern of Maged1 roughly summarizes that of Maged2 and Maged3 PMID: 15162511
    16. necdin and MAGE-D1 cooperate to modulate the function of Dlx/Msx homeodomain proteins in cellular differentiation PMID: 15272023
    17. Our results suggest that interaction of cytosolic PrP and NRAGE could affect neuronal viability. PMID: 15911347
    18. NRAGE as an integral component in bone morphogenetic proteins signaling and clarify its role during neural progenitor development PMID: 16107717
    19. NRAGE plays an important role in apoptotic-signaling in vivo. PMID: 18772898
    20. NRAGE might have multiple roles during renal branching morphogenesis through association with both the BMP and GDNF signaling pathways. PMID: 19268530
    21. The netrin receptor UNC5H1 induces apoptosis through and interaction with NRAGE. PMID: 12598531

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 组织特异性：
    Ubiquitously expressed in many adult tissues, except for the spleen. Expressed in osteoblastic and chondrogenic cell lines and also during embryonic development.
  • 数据库链接：

    KEGG: mmu:94275

    STRING: 10090.ENSMUSP00000026142

    UniGene: Mm.27578