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MZF1 Antibody

  • 货号：
    CSB-PA015389LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate
      All lanes: MZF1 antibody at 7.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 83, 55, 32 kDa
      Observed band size: 55 kDa
    • IHC image of CSB-PA015389LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA015389LA01HU diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MZF1 Polyclonal antibody
  • Uniprot No.：
    P28698
  • 基因名：
    MZF1
  • 别名：
    Myeloid zinc finger 1 antibody; MZF 1 antibody; MZF-1 antibody; MZF1 antibody; MZF1_HUMAN antibody; MZF1B antibody; Zfp98 antibody; Zinc finger and SCAN domain containing protein 6 antibody; Zinc finger and SCAN domain-containing protein 6 antibody; Zinc finger protein 42 antibody; ZNF42 antibody; ZSCAN6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Myeloid zinc finger 1 protein (186-354AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MZF1 Antibody (CSB-PA015389LA01HU)，的标记方式是Non-conjugated。对于MZF1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015389LB01HU MZF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA015389LC01HU MZF1 Antibody, FITC conjugated
    Biotin CSB-PA015389LD01HU MZF1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
  • 基因功能参考文献：
    1. Mechanistically, FTO enhanced MZF1 expression by reducing m(6)A levels and mRNA stability in MZF1 mRNA transcript, leading to oncogenic functions. PMID: 29842885
    2. MZF1 gene expression was not significantly correlated with PYROXD2 protein expression in the samples of resected tumor tissues, which revealed that the PYROXD2 promoter transcription activity was determined by the aggregated effect of numerous transcription factors. This finding may be helpful in understanding the underlying mechanism which regulates the PYROXD2 expression. PMID: 29048625
    3. PAX2 is involved in the carcinogenesis of endometrial cancer by stimulating cell growth and promoting cell motility; the overexpression of PAX2 in endometrial cancer is regulated by promoter hypermethylation and the transcription factor MZF1 PMID: 27764784
    4. miR-337-3p directly binds to the MMP-14 promoter to repress MZF1-facilitatd MMP-14 expression, thus suppressing the progression of gastric cancer PMID: 27259238
    5. TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway. PMID: 28703907
    6. SIRT6 over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 promoter chromatin structure makes it receptive to interaction with MZF1/SIRT6 complex, thereby favouring a regulatory state conducive to diminished transcription PMID: 28478957
    7. Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells. PMID: 28634046
    8. MZF1 has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1-SMAD4 axis, a new therapeutic target in advanced human gastric cancer. PMID: 27922669
    9. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation PMID: 25903835
    10. These findings suggest that PKCalpha expression in HCC could be stimulated by the formation of MZF-1/Elk-1 complex, which directly binds to the PKCalpha promoter. PMID: 26010542
    11. our results revealed that the loss of nuclear expression of MZF1 in oral squamous cell carcinoma (OSCC) samples can predict the progression of OSCC and the survival of OSCC patients in Taiwan PMID: 25877752
    12. The aberrant decreases in Ik-1 and MZF1 contribute significantly to the pathogenesis of NPM-ALK(+) T-cell lymphoma through the upregulation of IGF-IR expression. PMID: 25884514
    13. our results argue that MZF-1 regulates the CTGF and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma. PMID: 25899830
    14. Data indicate that elevated miR-492 expression in prostate tumors that resulted in diminished myeloid zinc-finger 1 (MZF-1) and ferroportin (FPN). PMID: 25284586
    15. Data suggest that induction of foxhead box M1(FOXM1) by E6 oncoprotein through the transcription factors MZF1/NKX2-1 axis may be responsible for human papillomavirus 16/18-mediated tumor progression. PMID: 25425970
    16. MZF1-mediated MYC expression may promote tumor progression, resulting in poor outcomes in cases of lung adenocarcinoma with low-wild-type-LKB1 tumors. PMID: 24793789
    17. MZF-1 binds to and positively regulates the GAPDH promoter. PMID: 25065746
    18. p55PIK is transcriptionally activated by MZF1, resulting in increased proliferation of colorectal cancer cells PMID: 23509792
    19. Selected single nucleotide polymorphisms in the MZF-1 gene exert a minor effect on the risk of Alzheimer's disease. PMID: 23241556
    20. This study shows that MZF-1 represses MMP-2 transcription and suggests that this repression may be linked to inhibition of human cervical cancer cell migration and metastasis. PMID: 22846578
    21. Expression levels of Elk-1 and PKCalpha were the highest in 5637 cells, but the MZF-1 expression observed in all five cell lines showed no significant difference. PMID: 22559731
    22. signaling network activates the transcription of cathepsin B gene via myeloid zinc finger-1 transcription factor that binds to an ErbB2-responsive enhancer element in the first intron of cathepsin B PMID: 22464443
    23. association between the expression of PKCalpha and the expression of the transcription factors Elk-1 and MZF-1 in breast cancer cell lines PMID: 22242952
    24. Taken together, this is the first study to show that MZF1 induces invasion and in vivo metastasis in colorectal and cervical cancer, at least in part by regulating Axl gene expression. PMID: 20145042
    25. MZF-1 and FHL3 formed a complex of high molecular mass with some additional proteins in the nucleus. Transcriptional repression of FcepsilonRI by MZF-1 required FHL3 as a cofactor. PMID: 15453830
    26. Sp1 and MZF1 are involved in the transcriptional regulation of the hST6GalNAc IV gene in Jurkat T cells PMID: 15528990
    27. MZF1 are important transcription factors regulating N-cadherin promoter activity and expression in osteoblasts. PMID: 15541732
    28. a transcription factor, MZF-1, was revealed to interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis PMID: 15670815
    29. PKCalpha expression may be modulated by Elk-1 and MZF-1 at the transcriptional level. PMID: 16297876
    30. Structure of MZF1 SCAN domain homodimer has been determined and provides an initial view of the recognition elements that govern dimerization for this large family of transcription factors. PMID: 16950398
    31. MZF1 and Sp1/Sp3 binding to the promoter region drive the PADI1 expression in keratinocytes PMID: 17851584
    32. These data suggest that APO can enhance the biosynthesis and release of FGF-2 through the activation of the MZF-1 transcription factor in striatal astrocytes PMID: 19196427

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts.
  • 数据库链接：

    HGNC: 13108

    OMIM: 194550

    KEGG: hsa:7593

    STRING: 9606.ENSP00000215057

    UniGene: Hs.399810