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MZB1 Antibody

  • 中文名称：
    MZB1兔多克隆抗体
  • 货号：
    CSB-PA893286
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q8WU39
  • 基因名：
    MZB1
  • 别名：
    MZB1 antibody; Caspase 2 binding protein antibody; FLJ32987 antibody; HSPC190 antibody; Marginal zone B and B1 cell specific protein antibody; Marginal zone B- and B1-cell-specific protein antibody; MEDA 7 antibody; MEDA-7 antibody; Mesenteric estrogen dependent adipose 7 antibody; Mesenteric estrogen-dependent adipose 7 antibody; Mesenteric oestrogen dependent adipose gene 7 antibody; MGC29506 antibody; Mzb1 antibody; MZB1_HUMAN antibody; PACAP antibody; pERp1 antibody; Plasma cell-induced ER protein 1 antibody; Plasma cell-induced resident endoplasmic reticulum protein antibody; Plasma cell-induced resident ER protein antibody; Proapoptotic caspase adapter protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 1-50
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.; Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
  • 基因功能参考文献：
    1. expression was positively correlated with a high accumulation of CD8(+) tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy PMID: 29180208
    2. Low MZB1 expression was an independent prognostic factor for recurrence after curative gastrectomy and was associated significantly with increased hematogenous recurrence. MZB1 acts as a suppressor of GC. Low MZB1 expression in the primary GC tissue is predictive of recurrence after curative resection. PMID: 27459504
    3. High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature. PMID: 23189934
    4. miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1. PMID: 24014023
    5. results suggested that MGC29506 has the potential of functioning as a novel suppressor gene in gastric cancer PMID: 23434460
    6. methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in hepatocarcinogenesis PMID: 22573353
    7. Data show that proapoptotic caspase adapter protein PACAP is a potential serum marker of non-small cell lung cancer. PMID: 22613335
    8. MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, was found to encode secreted-type protein with six conserved cysteine residues [MGC29506] PMID: 12792799

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  • 亚细胞定位：
    [Isoform 1]: Endoplasmic reticulum lumen. Secreted.; [Isoform 2]: Cytoplasm. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
  • 蛋白家族：
    MZB1 family
  • 组织特异性：
    Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.
  • 数据库链接：

    HGNC: 30125

    OMIM: 609447

    KEGG: hsa:51237

    STRING: 9606.ENSP00000303920

    UniGene: Hs.409563