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MYRIP Antibody

  • 货号：
    CSB-PA839876LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA839876LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA839876LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MYRIP Polyclonal antibody
  • Uniprot No.：
    Q8NFW9
  • 基因名：
    MYRIP
  • 别名：
    DKFZp586F1018 antibody; Exophilin 8 antibody; Exophilin antibody; Exophilin-8 antibody; Exophilin8 antibody; FLJ44025 antibody; MGC130034 antibody; MGC130035 antibody; Myosin VIIA and Rab interacting protein antibody; Myosin-VIIa- and Rab-interacting protein antibody; Myrip antibody; MYRIP_HUMAN antibody; Rab effector MyRIP antibody; SLAC 2C antibody; SLAC2 C antibody; SlaC2-c antibody; SLAC2C antibody; Slp homolog lacking C2 domains c antibody; Slp homologue lacking C2 domains antibody; Slp homologue lacking C2 domains c antibody; Synaptotagmin like protein homologue lacking C2 domains c antibody; synaptotagmin-like protein lacking C2 domains C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rab effector MyRIP protein (387-689AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MYRIP Antibody (CSB-PA839876LA01HU)，的标记方式是Non-conjugated。对于MYRIP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA839876LB01HU MYRIP Antibody, HRP conjugated ELISA
    FITC CSB-PA839876LC01HU MYRIP Antibody, FITC conjugated
    Biotin CSB-PA839876LD01HU MYRIP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release.
  • 基因功能参考文献：
    1. The role of MyRIP in Ca(2+)-driven exocytosis requires both MyoVa- and actin-binding potential. PMID: 26675235
    2. Myrip couples the retention of secretory granules in the cell cortex, their transport to the plasma membrane, and their attachment to the plasma membrane, thus promoting secretion. PMID: 22396429
    3. A Rab27a/MyRIP/myosin Va complex is involved in linking von-Willebrand factor (Vwf) to the peripheral actin cytoskeleton of endothelial cells to allow full maturation and prevent premature secretion of vWF. PMID: 21740491
    4. A new potentially protective effect was identified at rs2679798 in MYRIP. PMID: 20861866
    5. a molecular complex composed of Rab27A, MyRIP and myosin VIIa bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles PMID: 11964381
    6. Slac2c/MyRIP is part of a complex mediating the interaction of secretory granules with cortical actin cytoskeleton PMID: 14517322
    7. During primate spermiogenesis, dynein, myosin Va, MyRIP and Rab27b that compose microtubule-based and actin-based vesicle transport systems are actually present in the manchette and might possibly be involved in intramanchette transport. PMID: 18478159
    8. Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. PMID: 19270261
    9. Slac2-c/MyRIP contains an N-terminal Slp homology domain (SHD) and functions as a linker protein that interacts with myosin Rab27A/B, VIIa/Va, and actin. PMID: 12221080

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle.
  • 组织特异性：
    Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.
  • 数据库链接：

    HGNC: 19156

    OMIM: 611790

    KEGG: hsa:25924

    STRING: 9606.ENSP00000301972

    UniGene: Hs.594535