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MYOZ2 Antibody

  • 货号：
    CSB-PA873609LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate
      All lanes: MYOZ2 antibody at 4.31µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 30 kDa
      Observed band size: 30 kDa
    • IHC image of CSB-PA873609LA01HU diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA873609LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MYOZ2 Polyclonal antibody
  • Uniprot No.：
    Q9NPC6
  • 基因名：
    MYOZ2
  • 别名：
    C4orf5 antibody; Calcineurin binding protein calsarcin 1 antibody; Calsarcin 1 antibody; Calsarcin-1 antibody; Calsarcin1 antibody; CMH16 antibody; CS 1 antibody; CS1 antibody; FATZ related protein 2 antibody; FATZ-related protein 2 antibody; Muscle specific protein antibody; MYOZ 2 antibody; MYOZ2 antibody; MYOZ2_HUMAN antibody; Myozenin-2 antibody; Myozenin2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Myozenin-2 protein (90-180AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MYOZ2 Antibody (CSB-PA873609LA01HU)，的标记方式是Non-conjugated。对于MYOZ2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA873609LB01HU MYOZ2 Antibody, HRP conjugated ELISA
    FITC CSB-PA873609LC01HU MYOZ2 Antibody, FITC conjugated
    Biotin CSB-PA873609LD01HU MYOZ2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
  • 基因功能参考文献：
    1. may play a modifying role in hypertrophic cardiomyopathy by affecting the penetrance or degree of performance of the MYH7 gene PMID: 28296734
    2. The cardiac phenotype in hypertrophic cardiomyopathy caused by MYOZ2 mutations might be independent of calcineurin activity in the heart. PMID: 22987565
    3. Two missense mutations, S48P substitution and I246M affecting highly conserved amino acids were linked to hereditary Hypertrophic cardiomyopathy characterized by early onset of symptoms, pronounced cardiac hypertrophy, and cardiac arrhythmias. PMID: 17347475
    4. Mutations in MYOZ1 and MYOZ2 are at least very rare events as an underlying disease mechanism for idiopathic or familial DCM PMID: 17434779
    5. Observational study of genotype prevalence. (HuGE Navigator) PMID: 17347475

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  • 相关疾病：
    Cardiomyopathy, familial hypertrophic 16 (CMH16)
  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    Myozenin family
  • 组织特异性：
    Expressed specifically in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 1330

    OMIM: 605602

    KEGG: hsa:51778

    STRING: 9606.ENSP00000306997

    UniGene: Hs.732122