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MYOZ1 Antibody

  • 货号：
    CSB-PA904228
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA904228(MYOZ1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse muscle tissue, Primary antibody: CSB-PA904228(MYOZ1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9NP98
  • 基因名：
    MYOZ1
  • 别名：
    actinin- and telethonin-binding protein antibody; Calsarcin 2 antibody; Calsarcin-2 antibody; CS 2 antibody; FATZ antibody; Filamin, actinin and telethonin binding protein antibody; Filamin- antibody; MYOZ antibody; MYOZ1 antibody; MYOZ1_HUMAN antibody; Myozenin-1 antibody; Protein FATZ antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human MYOZ1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
  • 基因功能参考文献：
    1. Our results implicate MYOZ1 as the causative gene at the chromosome 10q22 locus for AF. PMID: 24177373
    2. Our findings provide evidence for a novel connection between the Z-disc protein calsarcin-2 and the sarcolemma via filamins and beta1 integrins. PMID: 16076904
    3. Mutations in PDLIM3 and MYOZ1, encoding myocyte Z line proteins, do not play any significant role in the genetic etiology of idiopathic DCM. PMID: 17254821
    4. A large number of variations were found in many of the genes (myozenin 1, gamma-filamin, kinectin-1) in patients with limb-girdle muscular dystrophies and controls. PMID: 19472918
  • 亚细胞定位：
    Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
  • 蛋白家族：
    Myozenin family
  • 组织特异性：
    Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas.
  • 数据库链接：

    HGNC: 13752

    OMIM: 605603

    KEGG: hsa:58529

    STRING: 9606.ENSP00000352272

    UniGene: Hs.238756