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  4. MYOG Antibody

MYOG Antibody

  • 货号：
    CSB-PA003347
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using Myogenin Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P15173
  • 基因名：
    MYOG
  • 别名：
    bHLHc3 antibody; cb553 antibody; Class C basic helix-loop-helix protein 3 antibody; MYF 4 antibody; Myf-4 antibody; MYF4 antibody; MYOG antibody; MYOG_HUMAN antibody; Myogenic factor 4 antibody; Myogenic factor 4 myogenin antibody; Myogenin antibody; Myogenin myogenin factor 4 antibody; OTTHUMP00000039094 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Myogenin.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.
  • 基因功能参考文献：
    1. Findings indicate a interplay between A-kinase anchoring protein 6 (AKAP6) and myogenin. PMID: 26563778
    2. results indicate that myogenin is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle PMID: 25044114
    3. Sustained GSK3beta activity represses a critical regulatory step in the myogenic cascade, contributing to the undifferentiated, proliferative phenotype in alveolar rhabdomyosarcoma. PMID: 24577092
    4. Our study illustrates that focal myogenin immunoreactivity occurs uncommonly in fibroepithelial polyps of the lower female genital tract. PMID: 23944986
    5. Data indicate that muscle MYOG mRNA expression doubled, whereas MSTN protein expression decreased following immobilization. PMID: 24215591
    6. the FACT complex promotes myogenin-dependent transcription PMID: 23364797
    7. Human muscle samples were analysed at different time-points post-denervation to evaluate changes in myogenin expression and their relationship with skeletal muscle atrophy. PMID: 21672341
    8. After 2 years of denervation, expression of myogenin protein in myonuclei was decreased, but after 3 years of denervation, no expression of myogenin protein in myonuclei was found in denervated posterior cricoarytenoid muscles. PMID: 19961777
    9. The physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under Tetradecanoylphorbol Acetate -induced differentiation. PMID: 20213728
    10. study showed that a rapid rearrangement of myogenin expression occurs in exercised human skeletal muscles in response to a single bout of exercise PMID: 14997318
    11. myogenin and myocyte enhancer factor-2 expression are triggered by membrane hyperpolarization during human myoblast differentiation PMID: 15084602
    12. induction of Id1 not only blocks transcriptional activity but also induces myogenin degradation by blocking formation of myogenin-E47 protein complexes. PMID: 15322112
    13. there is a functional link between dysferlin and myogenin in the differentiation of skeletal muscle PMID: 16608842
    14. MYOG is a positive diagnostic for biliary tract rhabdomyosarcoma. PMID: 17378682
    15. MYOG had positive staining in this melanotic neuroectodermal tumor. PMID: 17378694
    16. Both PCAF and BRG1 are also involved in the activation of the myogenin gene in rhabdomyosarcoma PMID: 17468105
    17. transcription of Cugbp1 gene in muscle is regulated by myogenin and E proteins PMID: 17531403
    18. Diffuse myogenin expression by immunohistochemistry is an independent marker of poor survival in pediatric rhabdomyosarcoma. PMID: 18708938
    19. PAX3 mRNA is an Staufen 1-mediated mRNA decay target whose decay promotes myogenesis whereas myogenin mRNA is a classical nonsense-mediated mRNA decay target encoding a protein required for myogenesis PMID: 19095803
    20. Underexpression of myogenin is associated with liver metastases in rhabdomyosarcoma. PMID: 19372547
    21. Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. PMID: 19470832

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 7612

    OMIM: 159980

    KEGG: hsa:4656

    STRING: 9606.ENSP00000241651

    UniGene: Hs.2830