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MYO1C Antibody

  • 货号：
    CSB-PA015340ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA015340ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA015340ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MYO1C Polyclonal antibody
  • Uniprot No.：
    O00159
  • 基因名：
    MYO1C
  • 别名：
    MMI beta antibody; MMI-beta antibody; MMIb antibody; MYO1C antibody; MYO1C_HUMAN antibody; Myosin I beta antibody; Myosin Ic antibody; Myosin-Ic antibody; MYR2 antibody; NMI antibody; Nuclear myosin I antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Unconventional myosin-Ic protein (804-1063AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.; Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.
  • 基因功能参考文献：
    1. E2 and NM1 associate via their N-terminal domains and this interaction is ATP dependent. PMID: 29179037
    2. The results establish a mechanistic connection between the calcium regulation of the motor function of myosin IC in the cytoplasm and the induction of its import into the nucleus. PMID: 27192697
    3. NTR(35), which harbors the R21G mutation, was unable to confer MYO1C(35)-like kinetic behavior. Thus, the NTRs affect the specific nucleotide-binding properties of MYO1C isoforms, adding to their kinetic diversity. We propose that this level of fine-tuning within MYO1C broadens its adaptability within cells. PMID: 28893906
    4. Cells expressing excess of MYO1C had low basal level of phosphorylated protein kinase B. PMID: 27716847
    5. Upon DNA damage, an increase in the levels of chromatin bound motor protein nuclear myosin 1 (NM1) ensues, which appears to be functionally linked to Upsilon-H2AX signaling. PMID: 27365048
    6. Study presents structural demonstration of a cargo protein, Neph1, attached to Myo1c, providing novel insights into the role of Myo1c in intracellular movements of this critical slit diaphragm protein. PMID: 27044863
    7. In glioblastoma 1321 N1 cells, we recently identified Myo1c as a new interactor of SHIP2. SHIP2 localization at lamellipodia and ruffles is impaired in Myo1c depleted cells. In the absence of Myo1c, N1 cells tend to associate to form clusters. PMID: 27246739
    8. Overexpression of MYO1C is associated with gastric cancer. PMID: 27468717
    9. Ablating MYO1C function causes abnormal cholesterol distribution, which has a major selective impact on the autophagy pathway PMID: 25551774
    10. Myo1c significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein tropomyosin 2 abolishes Myo1c-specific effects on both run initiation and run termination. PMID: 25660542
    11. NM1 phosphorylation by GSK3beta blocks NM1 ubiquitination by UBR5 and degradation by the proteasome, leads to NM1 association with the chromatin and promotes rDNA transcription activation at G1. PMID: 24901984
    12. The relationship between MYO1C and KAT6B suggests that the two are interacting in chromatin remodelling for gene expression in human masseter muscle. This is the nuclear myosin1 (NM1) function of MYO1C. PMID: 24698832
    13. myosin 1c manipulations lead to loss of the actin filaments and to similar endoplasmic reticulum phenotype as observed after actin depolymerization. PMID: 24523293
    14. The structural context and the chemical environment of Myo1c mutations that are involved in sensorineural hearing loss in humans are described and their impact on motor function is discussed. PMID: 24636949
    15. These results suggest a unique structural role for NM1 in which the interaction with SNF2h stabilizes B-WICH at the gene promoter and facilitates recruitment of the HAT PCAF PMID: 23555303
    16. Both nucleolar localization signals are functional and necessary for nucleolar localization of specifically myosin IC isoform B. PMID: 23438938
    17. This is the first report demonstrating that Myo1c is an important mediator of VEGF-induced VEGFR2 delivery to the cell surface and plays a role in angiogenic signaling. PMID: 23262137
    18. Myo1c regulates lipid raft recycling to control cell spreading, migration and Salmonella invasion. PMID: 22328521
    19. Myo1c plays a critical role in the translocation of Neph1 complexes in podocytes. Myo1c's ability to interact with membranes, F-actin, Neph1, and nephrin indicates that it actively contributes to the dynamic organization of the filtration slit. PMID: 21402783
    20. NM1 facilitates maturation and accompanies export-competent preribosomal subunits to the nuclear pore complex, thus modulating export. PMID: 19729515
    21. NM1 cooperates with a chromatin remodelling complex containing WSTF (Williams syndrome transcription factor) and SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A member 5 protein (SNF2h). PMID: 16514417
    22. WSTF-SNF2h-NM1 forms a platform in transcription while providing chromatin remodeling PMID: 16603771

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 数据库链接：

    HGNC: 7597

    OMIM: 606538

    KEGG: hsa:4641

    STRING: 9606.ENSP00000352834

    UniGene: Hs.286226