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MXD3 Antibody

  • 货号：
    CSB-PA015252LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA015252LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA015252LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MXD3 Polyclonal antibody
  • Uniprot No.：
    Q9BW11
  • 基因名：
    MXD3
  • 别名：
    bHLHc13 antibody; Class C basic helix-loop-helix protein 13 antibody; FLJ35523 antibody; Likely ortholog of mouse Max dimerization protein 3 antibody; MAD3_HUMAN antibody; MAX dimerization protein 3 antibody; Max dimerizer 3 antibody; Max-associated protein 3 antibody; Max-interacting transcriptional repressor MAD3 antibody; MGC2383 antibody; mxd3 antibody; Myx antibody; OTTHUMP00000223596 antibody; OTTHUMP00000223598 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Max dimerization protein 3 protein (1-206AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MXD3 Antibody (CSB-PA015252LA01HU)，的标记方式是Non-conjugated。对于MXD3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015252LB01HU MXD3 Antibody, HRP conjugated ELISA
    FITC CSB-PA015252LC01HU MXD3 Antibody, FITC conjugated
    Biotin CSB-PA015252LD01HU MXD3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
  • 基因功能参考文献：
    1. results indicate that MXD3 is a potential new target and that the use of MXD3 siRNA nanocomplexes is a novel therapeutic approach for neuroblastoma PMID: 28419087
    2. The results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor. PMID: 25554682
    3. Acute MXD3 activation results in a transient increase in DAOY cell proliferation while persistent activation of MXD3 results in an overall decrease in cell number, suggesting that the time course of MXD3 expression dictates the cellular outcome. PMID: 25053245
    4. Increased level and/or duration of MXD3 expression ultimately reduces cell numbers via increased cell death and cell cycle arrest in medulloblastoma cells. PMID: 22808009
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 14008

    OMIM: 609450

    KEGG: hsa:83463

    STRING: 9606.ENSP00000401867

    UniGene: Hs.743332