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  4. MTMR4 Antibody

MTMR4 Antibody

  • 货号：
    CSB-PA947266
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA947266(MTMR4 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA947266(MTMR4 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NYA4
  • 基因名：
  • 别名：
    FYVE domain containing dual specificity protein phosphatase 2 antibody; FYVE domain-containing dual specificity protein phosphatase 2 antibody; FYVE domain-containing dual specificity protein phosphatase FYVE DSP2 antibody; FYVE-DSP2 antibody; Mtmr4 antibody; MTMR4_HUMAN antibody; Myotubularin related protein 4 antibody; Myotubularin-related protein 4 antibody; ZFYVE11 antibody; zinc finger FYVE domain containing 11 antibody; Zinc finger FYVE domain containing protein 11 antibody; Zinc finger FYVE domain-containing protein 11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human MTMR4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
  • 基因功能参考文献：
    1. Here the s demonstrate that green fluorescent protein-tagged MTMR4 is recruited to the Salmonella-containing vacuole and infection of cells depleted of endogenous MTMR4 results in a decrease in viable intracellular Salmonella. PMID: 27625994
    2. the PH-GRAM domain of human MTMR4 was cloned, overexpressed in Escherichia coli, purified and crystallized by the vapour-diffusion method PMID: 25195910
    3. MTMR4 is a necessary negative modulator for the homeostasis of BMP/Dpp signaling PMID: 23150675
    4. MTMR4 localizes at the interface of early and recycling endosomes to regulate trafficking. PMID: 20736309
    5. MTMR4 belongs to the myotubularin family of phosphoinositides phosphatases PMID: 9736772
    6. MTMR4 plays an important role in preventing the overactivation of TGFbeta signaling by dephosphorylating activated R-Smads that have been trafficked to early endosomes PMID: 20061380
    7. Data found that hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. PMID: 19125695

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized to perinuclear region.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
  • 组织特异性：
    Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.
  • 数据库链接：

    HGNC: 7452

    OMIM: 603559

    KEGG: hsa:9110

    STRING: 9606.ENSP00000325285

    UniGene: Hs.514373