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MTERF1 Antibody

  • 货号：
    CSB-PA697477
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from Jurkat cells, using MTERF antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using MTERF antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MTERF1 Polyclonal antibody
  • Uniprot No.：
    Q99551
  • 基因名：
    MTERF1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human MTERF.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.
  • 基因功能参考文献：
    1. MTERF1 has the ability to accommodate alternate active conformations. PMID: 26523681
    2. It has been demonstrated that MTERF1 arrests mitochondrial DNA (mtDNA) replication with distinct polarity whereby MTERF1 acts as a directional contra-helicase, blocking mtDNA unwinding by the mitochondrial helicase TWINKLE. PMID: 27112570
    3. Studies indicate that the structure of the mitochondrial transcription termination factor (MTERF1) provides insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination. PMID: 21326908
    4. Single nucleotide polymorphism in MTERF gene is associated with epithelial ovarian cancer. PMID: 21447778
    5. data suggested that hMTERF4 is an essential factor for cell proliferation, which is probably modulated by mitochondrial transcription to promote cell proliferation PMID: 21450691
    6. Data show that mTERF protein levels materially affect the amount of readthrough transcription on the antisense strand of mtDNA, whilst the effects on sense-strand transcripts are complex, and suggest the influence of compensatory mechanisms. PMID: 20846394
    7. Presented are the crystal structures of human mitochondrial regulator MTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. PMID: 20543826
    8. The structure indicates that upon sequence recognition MTERF1 unwinds the DNA molecule, promoting eversion of three nucleotides. PMID: 20550934
    9. mTERF mRNA levels were higher in elite athletes compared with moderately active subjects PMID: 19681768
    10. mTERF exists in mitochondria in two forms, an active monomer and an inactive large size complex PMID: 14744862
    11. monomeric human mTERF is fully active in its non-phosphorylated form and that the protein does not require additional cellular factors to terminate mitochondrial transcription in vitro PMID: 15899902
    12. analysis of DNA light-strand preferential recognition of human mitochondria transcription termination factor mTERF PMID: 16336784
    13. Results indicate a role for mTERF in mtDNA replication, in addition to its role in transcription. PMID: 17884915

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    MTERF family
  • 数据库链接：

    HGNC: 21463

    OMIM: 602318

    KEGG: hsa:7978

    STRING: 9606.ENSP00000248643

    UniGene: Hs.532216