Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. MTBP Antibody

MTBP Antibody

  • 货号：
    CSB-PA856921LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA856921LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MTBP Polyclonal antibody
  • Uniprot No.：
    Q96DY7
  • 基因名：
    MTBP
  • 别名：
    hMTBP antibody; MDM 2 binding protein antibody; MDM 2 BP antibody; MDM2 (mouse double minute 2) binding protein 104kD antibody; MDM2 (mouse double minute 2) binding protein antibody; MDM2 binding protein antibody; MDM2 BP antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein antibody; Mdm2-binding protein antibody; MDM2BP antibody; Mouse double minute 2 homolog binding protein antibody; MTBP antibody; MTBP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mdm2-binding protein (567-724AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MTBP Antibody (CSB-PA856921LA01HU)，的标记方式是Non-conjugated。对于MTBP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA856921LB01HU MTBP Antibody, HRP conjugated ELISA
    FITC CSB-PA856921LC01HU MTBP Antibody, FITC conjugated
    Biotin CSB-PA856921LD01HU MTBP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
  • 基因功能参考文献：
    1. data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin. PMID: 26280083
    2. Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration. PMID: 25759210
    3. MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer . PMID: 24866769
    4. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development. PMID: 24786788
    5. MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. PMID: 23704573
    6. MTBP also inhibited ACTN4-mediated F-actin bundling. PMID: 22370640
    7. identification and characterization of mouse Mdm2 binding protein PMID: 10906133
    8. MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint. PMID: 21274008
    9. results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients PMID: 21692053
    10. Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. PMID: 15632057
    11. MTBP contributes to MDM2 activity and through this to negative regulation of p53 PMID: 15632057

    显示更多

    收起更多

  • 蛋白家族：
    MTBP family
  • 数据库链接：

    HGNC: 7417

    OMIM: 605927

    KEGG: hsa:27085

    STRING: 9606.ENSP00000303398

    UniGene: Hs.657656