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MT1E Antibody

  • 货号：
    CSB-PA17364A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA17364A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The MT1E antibody is a rabbit anti-MT1E human polyclonal antibody prepared using a synthetic polypeptide containing amino acids 4-59 of human MT1 as an immunogen. It exists as an unconjugated IgG isotype. It is only reactive with human samples. Its purity is 95%+ using protein G purified. This MT1E antibody has been validated for use in ELISA, IHC, and IF for the detection of the MT1E protein, which is highly expressed in motile cell lines and may play a role in enhancing the migration and invasion of human glioma cells.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MT1E Polyclonal antibody
  • Uniprot No.：
    P04732
  • 基因名：
    MT1E
  • 别名：
    MT1E antibody; Metallothionein-1E antibody; MT-1E antibody; Metallothionein-IE antibody; MT-IE antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Metallothionein-1E protein (4-59AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MT1E Antibody (CSB-PA17364A0Rb)，的标记方式是Non-conjugated。对于MT1E Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA17364B0Rb MT1E Antibody, HRP conjugated ELISA
    FITC CSB-PA17364C0Rb MT1E Antibody, FITC conjugated
    Biotin CSB-PA17364D0Rb MT1E Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
  • 基因功能参考文献：
    1. Forced MT1E expression rescues both hypersensitivity of CDKAL1 mutant cells to glycolipotoxicity and pancreatic beta-cell dysfunction in vitro and in vivo. PMID: 28538172
    2. MT1E can enhance the migration and invasion of human glioma cells by inducing MMP-9 inactivation via the upregulation of NF-kappaB p50. PMID: 22843066
    3. Our results reveal that menopause influences the adipose tissue expression of many genes, especially of neurexin 3, metallothionein 1E, and keratyn 7, which are associated with the alteration of several key biological processes. PMID: 21358552
    4. MT1E is a potential tumour suppressor gene, whose loss may promote resistance to apoptosis-inducing therapies. PMID: 20848733
    5. Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia. PMID: 20551211
    6. Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal ion transporter activity. PMID: 15747776
    7. analysis identified genes known to be associated with cell invasion such as versican, and novel ones, including metallothionein 1E (MT1E) and nicotinamide N-methyltransferase (NNMT) PMID: 18724390
    8. High frequency of hypermethylation of MT-1E was found in endometrial carcinomas. PMID: 19420986

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  • 蛋白家族：
    Metallothionein superfamily, Type 1 family
  • 数据库链接：

    HGNC: 7397

    OMIM: 156351

    KEGG: hsa:4493

    STRING: 9606.ENSP00000307706

    UniGene: Hs.744893