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MT-ND2 Antibody

  • 货号：
    CSB-PA015077GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P03891
  • 基因名：
  • 别名：
    MT-ND2 antibody; MTND2 antibody; NADH2 antibody; ND2 antibody; NADH-ubiquinone oxidoreductase chain 2 antibody; EC 7.1.1.2 antibody; NADH dehydrogenase subunit 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human ND2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
  • 基因功能参考文献：
    1. gene variants not associated with total fertilization failure PMID: 29577757
    2. The C5263T single-nucleotide mutation of the mitochondrial ND2 gene was observed in 2 young coronary heart disease (CHD) patients in the case group. The premature CHD of these 2 patients followed a pattern of maternal inheritance. PMID: 28494837
    3. Data show no association between the mitochondrial 5178C/A polymorphism of NADH-dehydrogenase subunit 2 (ND2) gene with type-2 diabetes mellitus (T2DM), however, the polymorphism may affect the development of nephropathy and hypertension complications. PMID: 26663065
    4. Study identified cancer-specific somatic variants in the ND2 and ND3 regions, and the presence of these mutated DNAs in the serum during the postoperative period accurately predicted poor prognoses in oral squamous cell carcinomas. PMID: 26179426
    5. This study did not show a correlation between ARMS2, C3, MT-NDH2, and CFH alleles in the development of choroid neovascularization associated with ocular histoplasmosis. PMID: 24612979
    6. The Mt5178 C/A genotype, which results in an amino acid polymorphism in NADH dehydrogenase subunit 2, may modify longitudinal changes in serum total cholesterol and high-density lipoprotein cholesterol levels in middle-aged Japanese men. PMID: 22351520
    7. demethylation of the D-loop plays a key role in regulating ND2 expression during the initiation and/or progression of colorectal cancer. PMID: 22505229
    8. For Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia PMID: 21702983
    9. Mutation T4681C disturbs the mitochondrial electron transport complex I assembly pathway and leads to Leigh syndrome. PMID: 16996290
    10. results suggest that ND2-237 Leu/Met polymorphism is associated with hypertension and that modification of hypertension risk is dependent on alcohol consumption in middle-aged Japanese men PMID: 17510502
    11. mitochondrial MTND2 polymorphism may increase susceptibility to nucleoside reverse transcriptase inhibitors associated peripheral neuropathy PMID: 17684475
    12. modifies the effects of coffee consumption on blood pressure or the risk of hypertension PMID: 19667492

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  • 相关疾病：
    Leber hereditary optic neuropathy (LHON); Alzheimer disease mitochondrial (AD-MT)
  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Complex I subunit 2 family
  • 数据库链接：

    HGNC: 7456

    OMIM: 502500

    KEGG: hsa:4536

    STRING: 9606.ENSP00000355046