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  4. Recombinant Human NADH-ubiquinone oxidoreductase chain 2 (MT-ND2), partial

Recombinant Human NADH-ubiquinone oxidoreductase chain 2 (MT-ND2), partial

  • 中文名称：
    人MT-ND2重组蛋白
  • 货号：
    CSB-YP015077HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MT-ND2重组蛋白
  • 货号：
    CSB-EP015077HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MT-ND2重组蛋白
  • 货号：
    CSB-EP015077HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MT-ND2重组蛋白
  • 货号：
    CSB-BP015077HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MT-ND2重组蛋白
  • 货号：
    CSB-MP015077HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    MT-ND2; MTND2; NADH2; ND2; NADH-ubiquinone oxidoreductase chain 2; EC 7.1.1.2; NADH dehydrogenase subunit 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
  • 基因功能参考文献：
    1. gene variants not associated with total fertilization failure PMID: 29577757
    2. The C5263T single-nucleotide mutation of the mitochondrial ND2 gene was observed in 2 young coronary heart disease (CHD) patients in the case group. The premature CHD of these 2 patients followed a pattern of maternal inheritance. PMID: 28494837
    3. Data show no association between the mitochondrial 5178C/A polymorphism of NADH-dehydrogenase subunit 2 (ND2) gene with type-2 diabetes mellitus (T2DM), however, the polymorphism may affect the development of nephropathy and hypertension complications. PMID: 26663065
    4. Study identified cancer-specific somatic variants in the ND2 and ND3 regions, and the presence of these mutated DNAs in the serum during the postoperative period accurately predicted poor prognoses in oral squamous cell carcinomas. PMID: 26179426
    5. This study did not show a correlation between ARMS2, C3, MT-NDH2, and CFH alleles in the development of choroid neovascularization associated with ocular histoplasmosis. PMID: 24612979
    6. The Mt5178 C/A genotype, which results in an amino acid polymorphism in NADH dehydrogenase subunit 2, may modify longitudinal changes in serum total cholesterol and high-density lipoprotein cholesterol levels in middle-aged Japanese men. PMID: 22351520
    7. demethylation of the D-loop plays a key role in regulating ND2 expression during the initiation and/or progression of colorectal cancer. PMID: 22505229
    8. For Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia PMID: 21702983
    9. Mutation T4681C disturbs the mitochondrial electron transport complex I assembly pathway and leads to Leigh syndrome. PMID: 16996290
    10. results suggest that ND2-237 Leu/Met polymorphism is associated with hypertension and that modification of hypertension risk is dependent on alcohol consumption in middle-aged Japanese men PMID: 17510502
    11. mitochondrial MTND2 polymorphism may increase susceptibility to nucleoside reverse transcriptase inhibitors associated peripheral neuropathy PMID: 17684475
    12. modifies the effects of coffee consumption on blood pressure or the risk of hypertension PMID: 19667492

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  • 相关疾病：
    Leber hereditary optic neuropathy (LHON); Alzheimer disease mitochondrial (AD-MT)
  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Complex I subunit 2 family
  • 数据库链接：

    HGNC: 7456

    OMIM: 502500

    KEGG: hsa:4536

    STRING: 9606.ENSP00000355046