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MT-CYB Antibody

  • 货号：
    CSB-PA616165
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 1,mouse-lung 2,mouse-brain 3,mouse-spleen 4,mouse-kidney 5,mouse-heart cells using primary antibody diluted at 1:500(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
  • 其他：

产品详情

  • Uniprot No.：
    P00156
  • 基因名：
  • 别名：
    COB antibody; Complex III subunit 3 antibody; Complex III subunit III antibody; CYB_HUMAN antibody; CYTB antibody; Cytochrome b antibody; Cytochrome b c1 complex subunit 3 antibody; Cytochrome b-c1 complex subunit 3 antibody; Mitochondrially encoded cytochrome b antibody; MT-CYB antibody; MTCYB antibody; Ubiquinol cytochrome c reductase complex cytochrome b subunit antibody; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human Cytochrome b. at AA range: 331-380
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-2000
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
  • 基因功能参考文献：
    1. The heteroplasmy level of some mutations in gene MT-CYB among women with asymptomatic atherosclerosis PMID: 29368910
    2. The effects of mutation in mitochondrially encoded cytochrome b are reviewed. PMID: 28132468
    3. Mitochondrial mutation m.15804T>C in the mtCYB gene in a family with fibromyalgia is associated with NLRP3-inflammasome activation. PMID: 26566881
    4. These results indicate that miR-151a-5p may participate in the regulation of cellular respiration and ATP production through targeting Cytb. PMID: 26626315
    5. The polymorphisms of CYTB as a very useful DNA marker were significantly different between different geographical Uyghur PMID: 24103151
    6. Significant elevation of ERalpha and MTCYB transcript levels in premenopausal leiomyomas and its association with ERalpha, -397 CC genotype suggests the mitochondrial-mediated role of estrogen as the promoter of leiomyoma tumorigenesis. PMID: 21506659
    7. mitocryptide-2 (MCT-2) and its human homolog hMCT-2 are cryptides that activate neutrophils PMID: 19342687
    8. The other proband had a non-synonymous G15221A mutation in the cytochrome b gene. PMID: 12031626
    9. In a mitochondrial myopathy patient, a novel stop-codon mutation (G15761A) was found in the mitochondrial DNA (mtDNA)-encoded cytochrome b gene, resulting in loss of the last 41 amino acids of the protein and complex III deficiency PMID: 12686403
    10. clinical/phenotypic variability of the G15498A mutation in mitochondrial DNA PMID: 14735157
    11. biochemical and molecular genetic studies of a patient with both muscle and brain involvement and a severe reduction in the activities of both complexes I and III in skeletal muscle due to a novel mutation in the MTCYB gene PMID: 16008558
    12. caspase 8-dependent cleavage of mitochondrial Cyt b and translocation of its C-terminal half into the cytoplasm occurred during FAS-induced apoptosis in both chicken and human cells PMID: 18796602
    13. CytbI7T has a role in longevity related to caloric restriction PMID: 19503808
    14. The m.15635T>C transition (S297P) was carried by a newborn who presented with a polyvisceral failure. PMID: 19563916
    15. cytochrome B gene mutation induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells. PMID: 19569044

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  • 相关疾病：
    Cardiomyopathy, infantile histiocytoid (CMIH); Leber hereditary optic neuropathy (LHON)
  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cytochrome b family
  • 数据库链接：

    HGNC: 7427

    OMIM: 500000

    KEGG: hsa:4519

    STRING: 9606.ENSP00000354554