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MSH4 Antibody

  • 货号：
    CSB-PA015030LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse lung tissue, Mouse kidney tissue, Human placenta tissue
      All lanes: MSH4 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 105 kDa
      Observed band size: 105 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA015030LA01HU at dilution of 1:100
    • Immunofluorescence staining of Hela cell with CSB-PA015030LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunofluorescence staining of Hela cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MSH4 Polyclonal antibody
  • Uniprot No.：
    O15457
  • 基因名：
    MSH4
  • 别名：
    hMSH4 antibody; MSH 4 antibody; MSH4 antibody; MSH4_HUMAN antibody; MutS homolog 4 (E. Coli) antibody; MutS homolog 4 antibody; MutS protein homolog 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human MutS protein homolog 4 protein (501-800AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MSH4 Antibody (CSB-PA015030LA01HU)，的标记方式是Non-conjugated。对于MSH4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015030LB01HU MSH4 Antibody, HRP conjugated ELISA
    FITC CSB-PA015030LC01HU MSH4 Antibody, FITC conjugated
    Biotin CSB-PA015030LD01HU MSH4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
  • 基因功能参考文献：
    1. Study describes the first MSH4 mutation associated with POI and increases the number of meiotic/DNA repair genes formally implicated as being responsible for this condition. PMID: 28541421
    2. inactivation of MSH4 in germ cells may have played a role in the acquisition of additional TP53 and LATS1 germline mutations in a Li-Fraumeni family PMID: 25041856
    3. hMSH4 interacts with HDAC3. PMID: 24145748
    4. Our current study has revealed a role for hMSH4 in the maintenance of genomic stability by suppressing NHEJ-mediated DSB repair. PMID: 23725059
    5. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages PMID: 21126912
    6. The different properties associated with these two hMSH5 variants underscore the potential functional diversity of the human hMSH5 gene. PMID: 15907804
    7. the GPS2 might function in concert with hMSH4-hMSH5 during the process of homologous recombination. PMID: 16122992
    8. A review of the properties and functional roles of MSH4. PMID: 17127347
    9. Dimerization of MSH4 and MSH5 facilitates their nuclear localization suggesting that dimerization may regulate the intracellular trafficking of these proteins. PMID: 17869244
    10. Data have identified the interaction region between the individual subunits of hMSH4-hMSH5 that are likely involved in clamp formation and show that each subunit of the heterodimer binds ATP. PMID: 17977839
    11. Data show that there is no association between MSH4 gene mutation and premature ovarian failure. PMID: 18166824

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  • 亚细胞定位：
    Chromosome.
  • 蛋白家族：
    DNA mismatch repair MutS family
  • 组织特异性：
    Testis and ovary specific.
  • 数据库链接：

    HGNC: 7327

    OMIM: 602105

    KEGG: hsa:4438

    STRING: 9606.ENSP00000263187

    UniGene: Hs.216639