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MS4A3 Antibody

  • 货号：
    CSB-PA856947LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of U251 cells using CSB-PA856947LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MS4A3 Polyclonal antibody
  • Uniprot No.：
    Q96HJ5
  • 基因名：
    MS4A3
  • 别名：
    MS4A3; CD20L; HTM4; Membrane-spanning 4-domains subfamily A member 3; CD20 antigen-like protein; Hematopoietic-specific transmembrane protein 4; HTm4
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Membrane-spanning 4-domains subfamily A member 3 protein (1-49AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MS4A3 Antibody (CSB-PA856947LA01HU)，的标记方式是Non-conjugated。对于MS4A3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA856947LB01HU MS4A3 Antibody, HRP conjugated ELISA
    FITC CSB-PA856947LC01HU MS4A3 Antibody, FITC conjugated
    Biotin CSB-PA856947LD01HU MS4A3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
  • 基因功能参考文献：
    1. These results suggest that cell surface expression of MS4A3 is useful to distinguish granulocyte/macrophage lineage-committed progenitors from other lineage-related ones in early human hematopoiesis. In conclusion, MS4A3 is useful to monitor early stage of myeloid differentiation in human hematopoiesis. PMID: 29274779
    2. a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8 PMID: 27579896
    3. Our data reveal MS4A3 as a novel direct target of EVI1 in human myeloid cells, and show that its repression plays a role in EVI1 mediated tumor aggressiveness. PMID: 25886616
    4. The C-terminal domain is important for the function of HTm4 in cell cycle regulation. PMID: 15830103
    5. High HTm4 is associated with neoplasms. PMID: 19818099

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  • 亚细胞定位：
    Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Located in the perinuclear area.
  • 蛋白家族：
    MS4A family
  • 组织特异性：
    Expressed specifically in hematopoietic cells and tissues.
  • 数据库链接：

    HGNC: 7317

    OMIM: 606498

    KEGG: hsa:932

    STRING: 9606.ENSP00000278865

    UniGene: Hs.99960