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MRPL58 Antibody

  • 货号：
    CSB-PA613490HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: MRPL58 antibody at 2µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Lane 3: K562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 24 kDa
      Observed band size: 24 kDa
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA613490HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA613490HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MRPL58 Polyclonal antibody
  • Uniprot No.：
    Q14197
  • 基因名：
    MRPL58
  • 别名：
    Digestion substraction 1 antibody; DS-1 antibody; DS1 antibody; Ict1 antibody; ICT1_HUMAN antibody; Immature colon carcinoma transcript 1 antibody; Immature colon carcinoma transcript 1 protein antibody; mitochondrial antibody; Peptidyl-tRNA hydrolase ICT1 antibody; Peptidyl-tRNA hydrolase ICT1, mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Peptidyl-tRNA hydrolase ICT1, mitochondrial protein (30-206AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MRPL58 Antibody (CSB-PA613490HA01HU)，的标记方式是Non-conjugated。对于MRPL58 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA613490HB01HU MRPL58 Antibody, HRP conjugated ELISA
    FITC CSB-PA613490HC01HU MRPL58 Antibody, FITC conjugated
    Biotin CSB-PA613490HD01HU MRPL58 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
  • 基因功能参考文献：
    1. High ICT1 expression is associated with leukemia. PMID: 29328466
    2. ICT1 overexpression notably predicted poor prognosis of gastric cancer patients. PMID: 28987942
    3. Study demonstrates that ICT1 overexpression correlates with malignant clinical features and poor prognosis of hepatocellular carcinoma (HCC) patients. Functionally, ICT1 promotes proliferation, cell cycle progression and inhibits apoptosis of HCC cells. ICT1 regulates the expressions of CDK1, cyclin B1, Bcl-2 and Bax, and is directly targeted by microRNA-134 (miR-134) in HCC cells. PMID: 29130100
    4. ICT1 may play a crucial role in promoting gastric cancer proliferation in vitro. PMID: 29036264
    5. The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity. PMID: 28826487
    6. our preliminary study reveals the important role of ICT1 in NSCLC cells that knockdown of ICT1 significantly suppressed cell proliferation, arrested cell cycle though altering expression cell cycle regulators, and promoted cell apoptosis. PMID: 27413166
    7. ICT1 knockdown significantly inhibited cell proliferation and migration, led to G2/M phase cell-cycle arrest, and triggered apoptosis via the intracellular AMPKa, SAPK/JNK, and PARP signaling pathways. PMID: 27411551
    8. ICT1 was significantly upregulated in diffuse large B-cell lymphoma tissues (DLBCL) and correlated with poor survival. Knockdown of ICT1 remarkably induced cell cycle G0/G phase arrest and apoptosis in DLBCL cells. PMID: 28629825
    9. ICT1 knockdown altered the expression of apoptosis- or cell cyclerelated proteins such as Bcl-2, caspase-3, CDK1, CDK2 and cyclin B. PMID: 28290601
    10. ICT1 may be essential for hydrolysis of prematurely terminated peptidyl-tRNA moieties in stalled mitoribosomes. PMID: 20186120

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Prokaryotic/mitochondrial release factor family, Mitochondrion-specific ribosomal protein mL62 subfamily
  • 组织特异性：
    Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.
  • 数据库链接：

    HGNC: 5359

    OMIM: 603000

    KEGG: hsa:3396

    STRING: 9606.ENSP00000301585

    UniGene: Hs.407955