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MRPL41 Antibody

  • 货号：
    CSB-PA003297
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using MRP-L41 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8IXM3
  • 基因名：
    MRPL41
  • 别名：
    39S ribosomal protein L27 homolog antibody; 39S ribosomal protein L41 antibody; 39S ribosomal protein L41 mitochondrial antibody; Bcl-2-interacting mitochondrial ribosomal protein L41 antibody; BMRP antibody; Cell proliferation-inducing gene 3 protein antibody; L41mt antibody; mitochondrial antibody; Mitochondrial ribosomal protein L41 antibody; MRP L27 antibody; MRP-L27 homolog antibody; MRP-L41 antibody; MRPL27 antibody; mRpL41 antibody; PIG3 antibody; Proliferation inducing gene 3 antibody; RM41_HUMAN antibody; RPML27 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MRP-L41.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
  • 基因功能参考文献：
    1. Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. PMID: 24160266
    2. Apoptosis-inducing ability of wild-type BMRP is blocked by Bcl-2 through several mechanisms. PMID: 22711503
    3. region of BMRP required for the interaction with Bcl-2 is very relevant for the cell death-inducing activity of the protein PMID: 21253851
    4. BMRP is a mitochondrial ribosomal protein involved in the regulation of cell death by apoptosis, probably affecting pathways mediated by Bcl-2 and caspases. PMID: 15547950
    5. mitochondrial ribosomal protein L41 (MRPL41) is localized in the mitochondria, stabilizes the p53 protein, and enhances its translocation to the mitochondria, thereby inducing apoptosis. PMID: 16024796
    6. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and p27(Kip1) levels under the growth inhibitory conditions. PMID: 16256947

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Mitochondrion-specific ribosomal protein mL41 family
  • 组织特异性：
    Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
  • 数据库链接：

    HGNC: 14492

    OMIM: 611846

    KEGG: hsa:64975

    STRING: 9606.ENSP00000360498

    UniGene: Hs.44017