MRGPRX1 Antibody
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货号:CSB-PA290385
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规格:¥1100
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图片:
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The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA290385(MRGPRX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA290385(MRGPRX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他:
产品详情
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Uniprot No.:Q96LB2
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基因名:
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别名:MRGPRX1; MRGX1; SNSR3; SNSR4; Mas-related G-protein coupled receptor member X1; Sensory neuron-specific G-protein coupled receptor 3/4
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宿主:Rabbit
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反应种属:Human
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免疫原:Synthetic peptide of Human MRGPRX1
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:1000-1:2000 IHC 1:25-1:100 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.
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基因功能参考文献:
- MRGPRX1 is a promising target for pain inhibition, a humanized mouse model expressing this receptor has been described. PMID: 28223516
- Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1. In summary, activation of Mrgprs by the allergen Der p1 may contribute to inflammation. PMID: 28768771
- analysis of the functional interactions between MRGPR-X1 and TRPV1 PMID: 23074220
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亚细胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 1 family, Mas subfamily
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组织特异性:Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
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数据库链接:
HGNC: 17962
OMIM: 607227
KEGG: hsa:259249
STRING: 9606.ENSP00000305766
UniGene: Hs.711459
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