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MPI Antibody

  • 中文名称：
    MPI兔多克隆抗体
  • 货号：
    CSB-PA014754ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: MPI antibody at 5.12µg/ml
      Lane 1: Mouse heart tissue
      Lane 2: Mouse kidney tissue
      Lane 3: Mouse brain tissue
      Lane 4: HepG2 whole cell lysate
      Lane 5: 293T whole cell lysate
      Lane 6: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 47, 40 kDa
      Observed band size: 47 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA014754ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA014754ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MPI Polyclonal antibody
  • Uniprot No.：
    P34949
  • 基因名：
    MPI
  • 别名：
    ody; CDG1B antibody; FLJ39201 antibody; Mannose 6 phosphate isomerase antibody; Mannose-6-phosphate isomerase antibody; MANNOSEPHOSPHATE ISOMERASE antibody; MGC94106 antibody; MPI antibody; MPI_HUMAN antibody; Phosphohexomutase antibody; phosphomannose isomerase 1 antibody; Phosphomannose isomerase antibody; PMI antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Mannose-6-phosphate isomerase protein (1-423AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
  • 基因功能参考文献：
    1. This work provides mechanistic evidence by which mannose phosphate isomerase loss induces p53, and identifies mannose phosphate isomerase as a novel regulator of p53 and Warburg metabolism. PMID: 28644127
    2. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts PMID: 21949237
    3. The mannose-6-phosphate-enzyme complex is developed and the key residues involved in the ligand binding are determined. Our results suggest a hydride transfer mechanism of alpha-hydrogen between the C1 and C2 positions. PMID: 16488169
  • 相关疾病：
    Congenital disorder of glycosylation 1B (CDG1B)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Mannose-6-phosphate isomerase type 1 family
  • 组织特异性：
    Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
  • 数据库链接：

    HGNC: 7216

    OMIM: 154550

    KEGG: hsa:4351

    STRING: 9606.ENSP00000318318

    UniGene: Hs.75694