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MPC2 Antibody

  • 货号：
    CSB-PA002816LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse kidney tissue
      All lanes: MPC2 antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 15 kDa
      Observed band size: 15 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA002816LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA002816LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MPC2 Polyclonal antibody
  • Uniprot No.：
    O95563
  • 基因名：
    MPC2
  • 别名：
    MPC2; BRP44; Mitochondrial pyruvate carrier 2; Brain protein 44
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Mitochondrial pyruvate carrier 2 protein (1-40AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MPC2 Antibody (CSB-PA002816LA01HU)，的标记方式是Non-conjugated。对于MPC2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA002816LB01HU MPC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA002816LC01HU MPC2 Antibody, FITC conjugated
    Biotin CSB-PA002816LD01HU MPC2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates the uptake of pyruvate into mitochondria.
  • 基因功能参考文献：
    1. Hypoxia induces lactate secretion and glycolytic efflux by downregulating MPC1/MPC2 levels in HUVEC cells. PMID: 29845198
    2. Our study indicates that MPC1 and MPC2 expressions are of prognostic values in PCAs and that positive expression of MPC1 or MPC2 is a predictor of favorable outcome. PMID: 27852261
    3. a significant association between MPC2 variant rs10489202 and Schizophrenia susceptibility in Han Chinese (Meta-Analysis) PMID: 27460766
    4. Results indicate mitochondrial pyruvate transporter (MPC) to be the key regulatory junction perturbed by virulent strains of Mycobacterium tuberculosis leading to alteration of mitochondrial metabolic flux and regulation of acetyl-CoA formation. PMID: 28263840
    5. Tumor cells expressing MPC1 and MPC2 display increased mitochondrial pyruvate oxidation, with no changes in cell growth in adherent culture. PMID: 25458841
    6. found no significant difference (P > 0.05) in either allele or genotype frequency in the SNPs between patients and controls. PMID: 23933155
    7. characterization of the rat ortholog PMID: 3022128

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  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
  • 数据库链接：

    HGNC: 24515

    OMIM: 614737

    KEGG: hsa:25874

    STRING: 9606.ENSP00000271373

    UniGene: Hs.517768