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MORF4L2 Antibody

  • 货号：
    CSB-PA014723GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q15014
  • 基因名：
    MORF4L2
  • 别名：
    KIAA0026 antibody; MO4L2_HUMAN antibody; MORF related gene X protein antibody; MORF-related gene X protein antibody; Morf4l2 antibody; MORFL2 antibody; Mortality Factor 4 like 2 antibody; Mortality factor 4 like protein 2 antibody; Mortality factor 4-like protein 2 antibody; MRGX antibody; MSL3 2 protein antibody; Protein MSL3-2 antibody; Transcription factor like protein MRGX antibody; Transcription factor-like protein MRGX antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MORF4L2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
  • 基因功能参考文献：
    1. Suberoylanilide hydroxamic acid enhanced the expression of malignant genes such as MORF4L2 in lung cancer cells remaining after treatment, creating a more drug-resistant state. PMID: 25796627
    2. can repress or activate the B-myb promoter depending on the cell type studied, suggesting that there may be tissue-specific functions of this protein PMID: 14506250
    3. The transcriptional status of four key genes, thymidylate synthase (TYMS), MORF-related gene X (MRGX), Bcl2-antagonist/killer (BAK), and ATPase, Cu(2+) transporting beta polypeptide (ATP7B), can accurately predict response to 5-FU. PMID: 18593893
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 16849

    OMIM: 300409

    KEGG: hsa:9643

    STRING: 9606.ENSP00000353643

    UniGene: Hs.326387