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MORC2 Antibody

  • 货号：
    CSB-PA896555LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: MORC2 antibody at 6μg/ml
      Lane 1: U87 whole cell lysate
      Lane 2: U251 whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Lane 4: Hela whole cell lysate
      Lane 5: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 118, 111 kDa
      Observed band size: 118 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA896555LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MORC2 Polyclonal antibody
  • Uniprot No.：
    Q9Y6X9
  • 基因名：
    MORC2
  • 别名：
    AC004542.C22.1. antibody; CW type with coiled coil domain 1 antibody; KIAA0852 antibody; MORC family CW type zinc finger 2 antibody; MORC family CW-type zinc finger protein 2 antibody; MORC2 antibody; MORC2_HUMAN antibody; ZCW3 antibody; ZCWCC1 antibody; Zinc finger antibody; Zinc finger CW type coiled coil domain protein 1 antibody; Zinc finger CW type with coiled coil domain 1 antibody; Zinc finger CW-type coiled-coil domain protein 1 antibody; Zing finger CW type 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human MORC family CW-type zinc finger protein 2 protein (2-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MORC2 Antibody (CSB-PA896555LA01HU)，的标记方式是Non-conjugated。对于MORC2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896555LB01HU MORC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA896555LC01HU MORC2 Antibody, FITC conjugated
    Biotin CSB-PA896555LD01HU MORC2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing. Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA. Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9. Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation.
  • 基因功能参考文献：
    1. For the first time, to the best of our knowledge, the present study confirmed that MORC2 was a novel oncogene in liver cancer. These results provide useful insight into the mechanism underlying the tumorigenesis and progression of liver cancer, and offers clues into potential novel liver cancer therapies. PMID: 29620211
    2. defects lead to the modulation of HUSH function, thus providing a molecular basis for understanding MORC2-associated neuropathies PMID: 29440755
    3. results thus contribute to the knowledge of the regulatory mechanism of HSF1 in down-regulating ArgBP2, providing new insight into the HSF1&MORC2-PRC2-ArgBP2 signaling pathway and a better understanding of their functions in gastric cancer cells. PMID: 29339121
    4. Differential viral accessibility shows that loss of MORC2 results in chromatin decompaction at HUSH complex target loci, concomitant with a loss of H3K9me3 deposition and transcriptional derepression. The ATPase activity of MORC2 is critical for HUSH-mediated silencing. The most common alteration affecting the ATPase domain in CMT patients (p.Arg252Trp) hyperactivates HUSH-mediated repression in neuronal cells. PMID: 28581500
    5. have identified a new locus in which MORC2 mutations are the likely pathogenic cause of CMT2 and pyramidal signs in these families. PMID: 26659848
    6. identified two different mutations in the MORC2 gene in patients from three unrelated families presenting with an axonal motor and sensory neuropathy. PMID: 26497905
    7. MORC2 down-regulates the ArgBP2 via histone methylation in gastric cancer cells. PMID: 26476214
    8. MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. PMID: 26098774
    9. PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis PMID: 25888627
    10. these results demonstrate a cytosolic function of MORC2 in lipogenesis, adipogenic differentiation, and lipid homeostasis by regulating the activity of ACLY. PMID: 24286864
    11. the PAK1-MORC2 axis is critical for orchestrating the interplay between chromatin dynamics and the maintenance of genomic integrity through sequentially integrating multiple essential enzymatic processes. PMID: 23260667
    12. Analysis of MORC2 functional domains, subcellular localization and mRNA and protein expression demonstrates its role of nuclear localization in association with a proline-rich domain regulating gene transcriptional repression in cancer cells. PMID: 20225202

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  • 相关疾病：
    Charcot-Marie-Tooth disease 2Z (CMT2Z)
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol. Chromosome. Nucleus matrix.
  • 组织特异性：
    Highly expressed in smooth muscle, pancreas and testis.
  • 数据库链接：

    HGNC: 23573

    OMIM: 616661

    KEGG: hsa:22880

    STRING: 9606.ENSP00000215862

    UniGene: Hs.555918