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MOB1B Antibody

  • 货号:
    CSB-PA788447
  • 规格:
    ¥1100
  • 图片:
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, K562 cells, Primary antibody: CSB-PA788447(MOB1B Antibody) at dilution 1/112.5, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他:

产品详情

  • Uniprot No.:
    Q7L9L4
  • 基因名:
  • 别名:
    MATS 2 antibody; MATS2 antibody; MGC33910 antibody; Mob 1A antibody; Mob 1B antibody; MOB 4A antibody; MOB kinase activator 1B antibody; Mob1 homolog 1A antibody; MOB1 Mps One Binder homolog B antibody; MOB1 Mps one binder kinase activator like 1A antibody; Mob1A antibody; Mob1B antibody; MOBKL 1A antibody; MOBKL1A antibody; MOL1A_HUMAN antibody; Mps one binder kinase activator like 1A antibody; Mps one binder kinase activator-like 1A antibody; Protein Mob4A antibody
  • 宿主:
    Rabbit
  • 反应种属:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human MOB1B
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated
  • 抗体亚型:
    IgG
  • 纯化方式:
    Antigen affinity purification
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA,WB
  • 推荐稀释比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能:
    Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
  • 亚细胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    MOB1/phocein family
  • 组织特异性:
    Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.
  • 数据库链接:

    HGNC: 29801

    OMIM: 609282

    KEGG: hsa:92597

    STRING: 9606.ENSP00000310189

    UniGene: Hs.691454