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MOAP1 Antibody

  • 货号：
    CSB-PA014693ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MOAP1 Polyclonal antibody
  • Uniprot No.：
    Q96BY2
  • 基因名：
    MOAP1
  • 别名：
    MAP 1 antibody; MAP-1 antibody; MAP1 antibody; MOAP1 antibody; MOAP1_HUMAN antibody; Modulator of apoptosis 1 antibody; Modulator of Apoptosis antibody; Paraneoplastic antigen like 4 antibody; Paraneoplastic antigen Ma4 antibody; paraneoplastic Ma antigen family member 4 antibody; PNMA4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Modulator of apoptosis 1 protein (1-351AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
  • 基因功能参考文献：
    1. RACK1 associates with MOAP-1 via electrostatic associations similar to those observed between MOAP-1/RASSF1A and MOAP-1/TNF-R1. These events illustrate the complex nature of MOAP-1 regulation and characterizes the important role of the scaffolding protein, RACK1, in influencing MOAP-1 biology. PMID: 29470995
    2. These findings reveal a role for MOAP-1 in Fas signaling in the liver by promoting MTCH2-mediated tBid recruitment to mitochondria. PMID: 27320914
    3. UBR5 downregulates proapoptotic MOAP-1 and suggest that UBR5 can confer cisplatin resistance in ovarian cancer. PMID: 27721409
    4. Paraneoplastic Ma antigen-like 1 is suggested as a novel potential clinically useful prognostic biomarker for patients with pancreatic ductal adenocarcinoma. PMID: 25251443
    5. PNMA2 functions as antagonist of MOAP-1 and PNMA1 through heterodimeric interaction PMID: 27003254
    6. MOAP-1 is a tumor suppressor protein linked to the RASSF1A protein PMID: 26269600
    7. miR-25 promotes cell proliferation and inhibits apoptosis in non-small cell lung cancer cells by negatively regulating MOAP1 expression. PMID: 25998847
    8. PB1-F2 protein of influenza A virus interacts with human MOAP-1 protein. PMID: 23236846
    9. Enforced miR-1228 expression can reduce MOAP1 expression and delay the progression of stress-induced cell apoptosis. PMID: 22434376
    10. RASSF1A and MAP-1 are important components between death receptors and the apoptotic machenery. PMID: 15949439
    11. RASSF1A is a tumor suppressor that activates Bax via MOAP-1 PMID: 16344548
    12. Inhibition of ubiquitin-mediated degradation of MOAP1 by apoptotic stimuli promotes BAX function in mitochondria. PMID: 17535899
    13. The association of RASSF1A and MOAP-1 with death receptors involves an ordered recruitment to receptor complexes to promote cell death and inhibit tumor formation. PMID: 18474619

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  • 蛋白家族：
    PNMA family
  • 组织特异性：
    Widely expressed, with high levels in heart and brain.
  • 数据库链接：

    HGNC: 16658

    OMIM: 609485

    KEGG: hsa:64112

    STRING: 9606.ENSP00000298894

    UniGene: Hs.24719