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MNT Antibody

  • 货号：
    CSB-PA003261
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using MNT Polyclonal Antibody
    • Western Blot analysis of Jurkat cells using MNT Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q99583
  • 基因名：
  • 别名：
    bHLHd3 antibody; Class D basic helix-loop-helix protein 3 antibody; MAD6 antibody; MAX binding protein antibody; Max binding protein MNT antibody; MAX network transcriptional repressor antibody; Max-binding protein MNT antibody; Mnt antibody; MNT_HUMAN antibody; MXD6 antibody; Myc antagonist MNT antibody; Protein ROX antibody; ROX antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MNT.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
  • 基因功能参考文献：
    1. In vitro, uremia induced dysregulation of DNA methylation in differentiating monocytes, which affected several transcription regulators important for monocyte differentiation (e.g., FLT3, HDAC1, MNT) and led to enhanced generation of intermediate monocytes. PMID: 27018948
    2. The data demonstrate that the balance between c-Myc and Mnt activity determines the transcriptional outcome of the hTERT promoter by modulation of the chromatin architecture. PMID: 23860446
    3. The results suggest that MNT, via interaction with Nck1, inhibits hepatoma cell migration. PMID: 22964333
    4. downregulation MYCN was reflected in a decreased MYCN/Max DNA-binding activity while the Mnt/Max binding did not change during differentiation PMID: 15258910
    5. Serum stimulation of quiescent cells results in phosphorylation of Mnt and disruption of the critical Mnt-mSin3-HDAC1 interaction. This in turn leads to increased expression of the Myc/Mnt target gene cyclin D2. Review. PMID: 17419941

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 7188

    OMIM: 603039

    KEGG: hsa:4335

    STRING: 9606.ENSP00000174618

    UniGene: Hs.626579