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MMS19 Antibody

  • 中文名称：
    MMS19兔多克隆抗体
  • 货号：
    CSB-PA014682GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96T76
  • 基因名：
    MMS19
  • 别名：
    hMMS19 antibody; homolog of yeast MMS19 antibody; MET18 antibody; MET18 homolog antibody; MET18MMS19 nucleotide excision repair homolog (S. cerevisiae) antibody; mms19 antibody; MMS19 nucleotide excision repair protein homolog antibody; MMS19 nucleotide excision repair, S. cerevisiae, homolog of antibody; MMS19-like (MET18 homolog, S. cerevisiae) antibody; MMS19-like protein antibody; MMS19_HUMAN antibody; MMS19L antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MMS19
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
  • 基因功能参考文献：
    1. findings suggest that MMS19 plays an essential role in maintaining mitochondrial genome stability PMID: 29035693
    2. POLE1 is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. PMID: 27235625
    3. We therefore propose the expression level of MMS19 as a candidate predictive marker of ACT benefit in resected NSCLC patients. PMID: 27802208
    4. Suggest that MMS19 may be a potential new predictor of metastasis and chemoradiotherapy response in esophageal squamous cell carcinoma. PMID: 25892874
    5. MMS19L polymorphisms are associated with response to chemotherapy in osteosarcoma. PMID: 23886164
    6. Single nucleotide polymorphisms in the MMS19L gene is associated with bone malignant tumors. PMID: 23679317
    7. Polymorphisms in ERCC1, codon-118 and MMS19 genes are not associated with clinical response to platinum or survival. PMID: 23632208
    8. MMS19 interacts with target proteins. MIP18 has a role to bridge MMS19 and CIAO1. CIAO1 also binds IOP1. PMID: 23585563
    9. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. PMID: 23150669
    10. study demonstrates MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1 and MIP18; cytoplasmic MMS19 also binds to multiple nuclear Fe-S proteins involved in DNA metabolism; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair PMID: 22678361
    11. identified MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery; MMS19 functions as part of the CIA targeting complex that interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance PMID: 22678362
    12. Results indicate that the MMS19-XPD protein complex is required for proper chromosome segregation, an abnormality of which could contribute to the pathogenesis in some cases of xeroderma pigmentosum. PMID: 20797633
    13. Cloning of the human MMS19 genes and functional complementation in Saccharomyces cerevisiae PMID: 11328871
    14. MMS19 HEAT repeat domain is essential for MMS19 function in NER and transcription, while domains A and B, within MMS19 N-terminus, modulate the balance between DNA repair and transcription. PMID: 16797255
    15. Single nucleotide polymorphisms in MMS19L is associated with pancreatic cancer. PMID: 19318433

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  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    MET18/MMS19 family
  • 组织特异性：
    Ubiquitously expressed with higher expression in testis.
  • 数据库链接：

    HGNC: 13824

    OMIM: 614777

    KEGG: hsa:64210

    STRING: 9606.ENSP00000359818

    UniGene: Hs.500721