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MMP17 Antibody

  • 货号：
    CSB-PA936376
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, human colon cancer tissue, Primary antibody: CSB-PA936376(MMP17 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9ULZ9
  • 基因名：
    MMP17
  • 别名：
    Matrix metalloproteinase 17 antibody; Matrix metalloproteinase 17 membrane inserted antibody; Matrix metalloproteinase-17 antibody; Membrane type 4 matrix metalloproteinase antibody; Membrane type matrix metalloproteinase 4 antibody; Membrane-type matrix metalloproteinase 4 antibody; Membrane-type-4 matrix metalloproteinase antibody; MMP 17 antibody; MMP-17 antibody; Mmp17 antibody; MMP17_HUMAN antibody; MT MMP 4 antibody; MT MMP4 antibody; MT-MMP 4 antibody; MT4 MMP antibody; MT4-MMP antibody; MT4MMP antibody; MTMMP 4 antibody; MTMMP4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human MMP17
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
  • 基因功能参考文献：
    1. MT4-MMP targeting may constitute a novel strategy to boost patrolling monocyte activity in early inflammation. PMID: 29500407
    2. Three forms of MT4-MMP with molecular masses of 45 kDa, 58 kDa and 69 kDa were detected. Further, we demonstrate that the 58 kDa form is the mature protein in the cell membrane, while the 69 kDa form is its precursor found in intracellular compartments. PMID: 28531887
    3. Low MT4-MMP expression is associated with erlotinib resistance in breast cancer. PMID: 28196064
    4. The MT4-MMP is internalized by the clathrin-independent carriers/GPI-enriched early endosomal compartments pathway, a mechanism that differs from that responsible for the internalization of other membrane-type MMP members. PMID: 26663028
    5. Screening of patients with inherited thoracic aortic aneurysms and dissections identified a missense mutation (R373H) in the MMP17 gene that prevented the expression of the protease in human transfected cells. PMID: 25963716
    6. A functional link between MT4-MMP and the growth factor receptor EGFR. PMID: 25320013
    7. CAV1 when found in lipid rafts does not allow the metalloproteinase MT4-MMP to localize into the lipid rafts, affecting its expression in the cell and probably its activity which is translated into the metastasis-associated activities of these cells. PMID: 22674854
    8. It identifies MT4-MMP as a key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination. PMID: 22262494
    9. MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation PMID: 19426156
    10. The data presented here provide a new insight into the characteristics of MT4-MMP and highlight the common and distinct properties of the glycosylphosphatidylinositol-anchored membrane type-matrix metalloproteinases. PMID: 21828052
    11. Studies suggest a model of hypoxia induced metastasis through expression of HIF-1alpha, and SLUG regulation of MT4-MMP transcription. PMID: 20019845
    12. Data show that eosinophils constitutively express membrane type-4 matrix metalloproteinase (MT4-MMP), which is increased upon stimulation with tumor necrosis factor-alpha. PMID: 12962706
    13. MT4-MMP and the proteoglycan form of syndecan-1 have roles in ADAMTS-4 activation on the cell surface PMID: 14701864

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  • 亚细胞定位：
    [Isoform Long]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
  • 数据库链接：

    HGNC: 7163

    OMIM: 602285

    KEGG: hsa:4326

    STRING: 9606.ENSP00000353767

    UniGene: Hs.709245