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MKRN1 Antibody

  • 货号：
    CSB-PA883390LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA883390LA01HU diluted at 1:600 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MKRN1 Polyclonal antibody
  • Uniprot No.：
    Q9UHC7
  • 基因名：
    MKRN1
  • 别名：
    E3 ubiquitin-protein ligase makorin-1 antibody; FLJ21334 antibody; HGNC:7112 antibody; Makorin antibody; Makorin ring finger protein 1 antibody; MKRN 1 antibody; mkrn1 antibody; MKRN1_HUMAN antibody; OTTHUMP00000212117 antibody; OTTHUMP00000212118 antibody; OTTHUMP00000212121 antibody; OTTHUMP00000212124 antibody; Ring finger protein 1 antibody; RING finger protein 61 antibody; RNF61 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase makorin-1 protein (109-209AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MKRN1 Antibody (CSB-PA883390LA01HU)，的标记方式是Non-conjugated。对于MKRN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA883390LB01HU MKRN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA883390LC01HU MKRN1 Antibody, FITC conjugated
    Biotin CSB-PA883390LD01HU MKRN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
  • 基因功能参考文献：
    1. HAdV-C5 histone-like core protein pVII binds to and promotes self-ubiquitination of a cellular E3 ubiquitin ligase named MKRN1. This mutual interaction between the pVII and MKRN1 proteins may prime MKRN1 for proteasomal degradation, because the MKRN1 protein is efficiently degraded during the late phase of HAdV-C5 infection. PMID: 29142133
    2. In combination testing, MKRN1 + HPV showed the highest sensitivity and specificity levels. The MKRN1 biomarker may be a useful adjunct in primary cervical cytology screening. PMID: 26817873
    3. EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase. PMID: 26183061
    4. Results verified MKRN1 as an ubiquitin E3 ligase of p14ARF, it potentially regulates cellular aging and tumorigenesis in gastric cancer. PMID: 23104211
    5. MKRN1 could induce WNV capsid protein ubiquitination and degradation in a proteasome-dependent manner PMID: 19846531
    6. MKRN1 may represent a nuclear protein with multiple nuclear functions, including regulating RNA polymerase II-catalyzed transcription. PMID: 16785614
    7. Data indicate that MKRN1 is a novel modulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21. PMID: 19536131
    8. Makorin 1 is a novel SEREX antigen of esophageal squamous cell carcinoma PMID: 19604354

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  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 7112

    OMIM: 607754

    KEGG: hsa:23608

    STRING: 9606.ENSP00000255977

    UniGene: Hs.744883