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MKL2 Antibody

  • 货号：
    CSB-PA891962LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, NIH/3T3 whole cell lysate
      All lanes: MKL2 antibody at 4.2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 119, 43, 52, 115, 120 kDa
      Observed band size: 119 kDa
    • IHC image of CSB-PA891962LA01HU diluted at 1:500 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MKL2 Polyclonal antibody
  • Uniprot No.：
    Q9ULH7
  • 基因名：
    MKL2
  • 别名：
    FLJ31823 antibody; Megakaryoblastic leukemia 2 antibody; megakaryoblastic leukemia 2 protein antibody; MKL/myocardin-like 2 antibody; MKL/myocardin-like protein 2 antibody; Mkl2 antibody; MKL2_HUMAN antibody; MRTF-B antibody; Myocardin-related transcription factor B antibody; NPD001 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human MKL/myocardin-like protein 2 protein (164-313AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MKL2 Antibody (CSB-PA891962LA01HU)，的标记方式是Non-conjugated。对于MKL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA891962LB01HU MKL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA891962LC01HU MKL2 Antibody, FITC conjugated
    Biotin CSB-PA891962LD01HU MKL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.
  • 基因功能参考文献：
    1. Taken together, these findings suggest that MKL1 and MKL2 are present at synapses and involved in dendritic spine maturation. PMID: 29335431
    2. Study showed that MRTF-A and MRTF-B were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer. PMID: 26498848
    3. While disruption of the MKL2:SRF axis has been associated with severe microcephaly and disordered brain development in multiple model systems, the role of this transcription factor complex has not been previously demonstrated in human brain development. PMID: 23692340
    4. There were multiple independent HIV integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. PMID: 24968937
    5. MKL1/2 depletion resulted in Ras activation, elevated p16 expression and hypophosphorylation of the retinoblastoma (Rb) protein in DLC1-deficient hepatocellular carcinoma cells. PMID: 23853104
    6. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas. PMID: 23672313
    7. study provides evidence that MKL1/2 mediates cancerous transformation in DLC1-deficient hepatocellular and mammary carcinoma cells PMID: 22139079
    8. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. PMID: 20607705
    9. dominant negative MKL2 blocked differentiation-induced expression of SRF target genes skeletal alpha-actin and alpha-myosin heavy chain and blocked differentiation of the myoblasts to myotubes in vitro. PMID: 14565952
    10. BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases. PMID: 17947237
    11. Myocardin-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[ PMID: 18056415
    12. RNA interference was used to investigate the contribution of the MRTF-SRF pathway to cytoskeletal dynamics in MDA-MB-231 breast carcinoma and B16F2 melanoma cells, in which basal MRTF-SRF activity is Rho-dependent. PMID: 19198601

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  • 相关疾病：
    A chromosomal aberration involving C11orf95 is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with C11orf95 produces a C11orf95-MKL2 fusion protein (PubMed:20607705).
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 29819

    OMIM: 609463

    KEGG: hsa:57496

    STRING: 9606.ENSP00000339086

    UniGene: Hs.49143