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MIF4GD Antibody

  • 货号：
    CSB-PA013827LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MIF4GD Polyclonal antibody
  • Uniprot No.：
    A9UHW6
  • 基因名：
    MIF4GD
  • 别名：
    MIF4GD antibody; SLIP1 antibody; MIF4G domain-containing protein antibody; SLBP-interacting protein 1 antibody; hSLIP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human MIF4G domain-containing protein (1-133AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MIF4GD Antibody (CSB-PA013827LA01HU)，的标记方式是Non-conjugated。对于MIF4GD Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013827LB01HU MIF4GD Antibody, HRP conjugated ELISA
    FITC CSB-PA013827LC01HU MIF4GD Antibody, FITC conjugated
    Biotin CSB-PA013827LD01HU MIF4GD Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
  • 基因功能参考文献：
    1. Results suggest that MIF4GD is a potential regulator of p27-dependent cell proliferation in HCC. PMID: 24336329
    2. Data suggest that oligomerization and SLBP phosphorylation regulate SLBP-SLIP1-histone-mRNA complex formation/disassociation; sequential and ordered assembly is required. PMID: 23286197
    3. This paper describes the oligomeric state of SLIP1 and the SLIP1-SLBP complex and how it is regulated by SLBP phosphorylation. Using alanine scanning mutagenesis, the s demonstrate that the binding site on SLIP1 for SLBP lies close to the dimer interface. A single-point mutant near the SLIP1 homodimer interface abolished interaction with SLBP in vitro and reduced the abundance of histone mRNA in vivo. PMID: 23286197
    4. INT6 and MIF4GD were observed to colocalize in cytoplasmic foci. It was concluded that INT6, by establishing interactions with MIF4GD and SLBP, plays an important role in translation of poly(A) minus histone mRNAs. PMID: 22532700
    5. downregulation of endogenous SLIP1 reduces the rate of translation of endogenous histone mRNA and also reduces cell viability. PMID: 18025107

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    MIF4GD family
  • 数据库链接：

    HGNC: 24030

    OMIM: 612072

    KEGG: hsa:57409

    UniGene: Hs.325631