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MGAT5B Antibody

  • 货号：
    CSB-PA013780GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q3V5L5
  • 基因名：
    MGAT5B
  • 别名：
    MGAT5B antibody; KIAA2008Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B antibody; EC 2.4.1.- antibody; EC 2.4.1.155 antibody; Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B antibody; GlcNAc-T Vb antibody; GNT-Vb antibody; hGnTVb antibody; Mannoside acetylglucosaminyltransferase 5B antibody; N-acetylglucosaminyl-transferase Vb antibody; N-acetylglucosaminyltransferase IX antibody; GNT-IX antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MGAT5B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.
  • 基因功能参考文献：
    1. we found a strong correlation between serum GnT-V activity and HDL-C concentration in human subjects PMID: 27659420
    2. ENPP3 is a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) PMID: 23960081
    3. The activity of GnT-Vb was stimulated over 4-fold in the presence of 10 mM Mn(++), and pH optimum for GnT-Vb was 8.0. PMID: 19846580
    4. GnT-IX is responsible for the synthesis of a unique oligosaccharide structure in the brain PMID: 12941944
    5. N-linked beta(1,6) branching has a role in cell-cell adhesion, cellular motility and neoplasm invasiveness PMID: 14561752
    6. following human GnT-IX and GnT-V transfection in COS cells, antibody specifically recognized GnT-IX, but not GnT-V, in the Golgi apparatus PMID: 16413118
    7. These results demonstrate that GnT-VB expression can modulate the rate of neurite outgrowth by affecting beta1 integrin-ECM interaction. PMID: 16606368
    8. GnT-Vb enzyme involved in the O-mannosyl glycosylation pathway, play an active role in modulating integrin and laminin-dependent adhesion and migration of human neuronal cells. PMID: 16857188
    9. GnT-Vb-mediated glycosylation of RPTPbeta promotes galectin-1 binding and RPTPbeta levels of retention on the cell surface. PMID: 18838383

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 18 family
  • 组织特异性：
    Predominantly expressed in brain. Expressed in all area of the adult and fetal brain Also expressed at much lower level in testis, spleen and thymus.
  • 数据库链接：

    HGNC: 24140

    OMIM: 612441

    KEGG: hsa:146664

    STRING: 9606.ENSP00000391227

    UniGene: Hs.144531